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pro vyhledávání: ''
Autor:
Jin-Zi Ji, Peng-Xin Ge, Qiong-Yu Mi, Ting Zhu, Ting Tai, Hong-Guang Xie, Li-Ping Jiang, Yi-Fei Li
Publikováno v:
British Journal of Pharmacology. 179:46-64
Background and purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic
Publikováno v:
British Journal of Pharmacology. 178:4501-4517
BACKGROUND AND PURPOSE The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whet
Autor:
Xiaofang Gao, Zuofeng Liu, Yu Wang, Minhui Li, Ping Li, Pengfan Qie, Dong Renhan, Xu Gaojie, Lijuan Su, Peng Jian, Bin Guang, Sisi Yu, Siyuan Liu, Huang Sheng, Jin Liu, Siqi Yu, Hu Wen, Tai Yang
Publikováno v:
British Journal of Pharmacology. 178:4741-4757
BACKGROUND AND PURPOSE Aberrant lipid metabolism is recognized as a key feature of cancer cells. Our initial research on MS-based analysis of lipids in a multiple myeloma (MM) cell line showed a significant accumulation of lipids in multiple myeloma
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Anne T. Nies, Elke Schaeffeler, Kathrin Klein, Kathleen M. Giacomini, Michel Eichelbaum, Matthias Schwab, Ute Hofmann, Claudia Neul, Stefan Winter
Publikováno v:
British Journal of Pharmacology. 178:1459-1474
Background and purpose The metabolic activity of cytochrome P450 (CYP) 2D6 is highly variable and CYP2D6 genotypes insufficiently explain the extensive and intermediate metabolic phenotypes, limiting the prediction of drug response plus adverse drug
Autor:
Eyasu Makonnen, Ulf Diczfalusy, Jürgen Burhenne, Alimuddin Zumla, Abiy Habtewold, Wondwossen Amogne, Getnet Yimer, Eleni Aklillu
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE In TB-HIV co-infection, prompt initiation of TB therapy is recommended but anti-retroviral treatment (ART) is often delayed due to potential drug-drug interactions between rifampicin and efavirenz. In a longitudinal cohort stud
Autor:
Limin Zhou, Jiajia Zhao, Long Hin Poon, Zi-wei Li, Kenneth K.W. To, Zhi-Xiu Lin, Yufeng Zhang, Jun Zhang, Yuanfeng Lyu, Zhong Zuo, Xiaoyu Yan
Publikováno v:
British Journal of Pharmacology. 178:582-599
Background and purpose Altered drug pharmacokinetics is a significant concern in non-alcoholic steatohepatitis (NASH) patients. Although high-fat high-cholesterol (HFHC) diet-induced NASH (HFHC-NASH) rats could simulate the typical dysregulation of c
Publikováno v:
British Journal of Pharmacology
Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ9 -tetrahydrocannabinol, including Δ9 -tetrahydrocannabinolic acid, Δ9 -tetrahydrocannabivarin,
Autor:
Huijun Sun, Kexin Liu, Jingjing Wu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Chong Wang, Xiaodong Ma, Yanna Zhu
Publikováno v:
Br J Pharmacol
Background and purpose Diclofenac is a widely used nonsteroidal anti-inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac-in
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Purine metabolism in mice and human differ in terms of uricase (Uox) activity as well as hypoxanthine phosphoribosyltransferase (HPRT) activity. The aim of this study was the establishment of high HPRT activity–Uox knockout