Zobrazeno 241 - 250
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Publikováno v:
British Journal of Pharmacology. 93:289-294
1. The non-steroidal anti-inflammatory drug (NSAID) benoxaprofen at concentrations of 15, 30 and 60 micrograms ml-1 caused a dose-related activation of superoxide generation by human polymorphonuclear leucocytes (PMNL) in vitro. 2. The protein kinase
Publikováno v:
British Journal of Pharmacology. 74:137-141
1 The effects of histamine and chemical analogues were examined on mitogen-stimulated human lymphocyte proliferation. 2 Compounds with selective agonist activity at either H1- or H2-receptors were found to inhibit proliferative responses, although N-
Publikováno v:
British Journal of Pharmacology. 93:139-145
1. In order to examine the role of airway epithelium in the responsiveness of smooth muscle in man, we measured the contractile responses to acetylcholine (ACh), histamine, and prostaglandin F2 alpha (PGF2 alpha) and the relaxation response to isopre
Autor:
A. Dray, P.B. Bradley
Publikováno v:
British Journal of Pharmacology. 57:599-602
The pharmacology of spontaneously active cholinoceptive neurones in the brain stem of rats anaesthetized with urethane has been investigated using microiontophoresis to administer muscarinic and nicotinic agonists and antagonists. 2. Acetylcholine (A
Publikováno v:
British Journal of Pharmacology. 96:693-701
1. Applications of capsaicin, nicotine and methacholine were made locally onto the nasal mucosa in human controls and patients suffering from hyperreactive nasal disorders. Perception of sensation was registered as a sympton score and secretion quant
Autor:
P.J. Gardiner
Publikováno v:
British Journal of Pharmacology. 87:45-56
TR4979, an analogue of prostaglandin E1 (PGE1) was evaluated on respiratory and non-respiratory isolated tissues known to contain heterogeneous or homogeneous populations of the two classes of prostanoid (prostaglandins and thromboxanes) receptors. T
Publikováno v:
British Journal of Pharmacology. 87:543-551
Two prostaglandin endoperoxide analogues, EP 035 and EP 157, behave as specific thromboxane receptor antagonists on isolated smooth muscle preparations such as rabbit aorta, dog saphenous vein and guinea-pig trachea. However, in human platelet-rich p
Autor:
James B.D. Palmer, Julia M. Polak, Mohamed A. Ghatei, PK Mulderry, A Cadieux, Francis M. Cuss, Peter J. Barnes, Stephen R. Bloom, David R. Springall
Publikováno v:
British Journal of Pharmacology. 91:95-101
In human airways synthetic human sequence calcitonin gene-related peptide (hCGRP), a novel peptide produced by alternative processing of mRNA from the calcitonin gene, caused concentration-dependent contraction of human bronchi (EC50 4.9 X 10(-9) M)
Autor:
Åke Wennmalm, T. Sonnenfeld
Publikováno v:
British Journal of Pharmacology. 71:609-613
1 Rings of vascular tissue (from rabbit aorta or human peripheral vein) were incubated at room temperature in Tyrode solution in the absence or presence of nicotine or indomethacin. 2 Addition of portions of the incubates to human platelet-rich plasm
Publikováno v:
British Journal of Pharmacology. 71:157-164
1 Burimamide selectively inhibited the formation of thromboxane A2 from prostaglandin endoperoxides by human platelet microsomes in a dose-dependent manner (IC50 = 2.5 x 10(-5) M). Burimamide was found to be equipotent to imidazole as a thromboxane s