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Publikováno v:
British Journal of Pharmacology. 179:1338-1352
BACKGROUND AND PURPOSE Prostacyclin mimetics express potent vsoactive effects via prostanoid receptors which are not defined unequivocally, as to date no study has considered sex as a factor. The aim of this study was to determine the contribution of
Autor:
Jin-Zi Ji, Peng-Xin Ge, Qiong-Yu Mi, Ting Zhu, Ting Tai, Hong-Guang Xie, Li-Ping Jiang, Yi-Fei Li
Publikováno v:
British Journal of Pharmacology. 179:46-64
Background and purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic
Autor:
Xiao Hu, Hui Ding, Su-Ying Cui, Yu Qin, Nurhumar Kurban, Yong-He Zhang, Hui-Ling Zhao, Xiang-Yu Cui, Yu-Tong Liu
Publikováno v:
British Journal of Pharmacology. 178:3696-3707
Background and purpose Mineralocorticoid receptors (MRs), glucocorticoid receptors (GRs) and corticotropin-releasing factor (CRF) in the paraventricular nucleus of hypothalamus (PVN) are involved in the response to stress. The present study investiga
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Dorothee Römermann, Ursula Seidler, Xiu Renjie, Gabriella di Stefano, Xinjie Tan, Steven R. Talbot, Qinghai Tan
Publikováno v:
British Journal of Pharmacology. 178:1018-1036
Background and purpose Constipation and intestinal obstructive episodes are major health problems in cystic fibrosis (CF) patients. Three FDA-approved drugs against constipation-prone irritable bowel syndrome were tested for their ability to increase
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Purine metabolism in mice and human differ in terms of uricase (Uox) activity as well as hypoxanthine phosphoribosyltransferase (HPRT) activity. The aim of this study was the establishment of high HPRT activity–Uox knockout
Publikováno v:
British Journal of Pharmacology. 176:1315-1327
Background and purpose We investigated the inhibitory effect and associated molecular mechanisms of tolvaptan on angiotensin II (AngII)-induced aldosterone production in vitro and in vivo. Experimental approach In vitro, H295R human adrenocarcinoma c
Autor:
Patrizia Campolongo, Michela Servadio, Maura Palmery, Viviana Trezza, Sara Schiavi, Veronica Cartocci, Valentina Pallottini, Francesca Melancia
Publikováno v:
British Journal of Pharmacology. 175:3699-3712
Background and purpose Autism spectrum disorder (ASD) is more commonly diagnosed in males than in females. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is an environmental risk factor of ASD. Male rats prenatally exposed to VPA sho
Autor:
Chen-Yu Zhang, Kai Li, Ying Ding, Ming-Xuan Zhou, Xiao Han, Yun Xia, Yan Wang, Xiao-Han Jiang, Wen-Yu Song, Chen Qiu, Peng Sun, Chong-Chong Yin
Publikováno v:
Br J Pharmacol
Background and purpose Intra-islet heparan sulfate (HS) plays an important role in the maintenance of pancreatic islet function. The aim of this study was to investigate the effect mechanism of HS loss on the functioning of islets in diabetic mice. E
Autor:
Jean-Michel Rigo, Scarlet Gallegos, Joris Comhair, Robert J. Harvey, Giovanni Morelli, A. Araya, Bert Brône, Nicol Romero, Loreto San Martin, Luis G. Aguayo
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: The precise mechanism/s of action of ethanol, although studied for many years, are not well understood. Like other drugs of abuse, ethanol affects dopamine levels in the nucleus accumbens (nAc), an important region of the meso