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Publikováno v:
British Journal of Pharmacology. 120:420-425
1 The depressor responses to histamine, in anaesthetized cats and dogs, have been shown to involve both histamine H1- and H2-receptors. 2 In both species, histamine caused dose-dependent falls in blood pressure. The dose-response curve could be displ
Publikováno v:
British Journal of Pharmacology. 120:494-503
1 A cascade superfusion technique has been developed for the differential bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) released from porcine aortic endothelial cells cultured on microcarriers, packed into a column and perfu
Publikováno v:
British Journal of Pharmacology. 119:1619-1627
1. Male, Long Evans rats were instrumented chronically with pulsed Doppler probes and intravascular catheters to allow assessment of regional haemodynamic changes during i.v. infusion of lipopolysaccharide (LPS, 150 micrograms kg-1 h-1). 2. In the pr
Publikováno v:
British Journal of Pharmacology. 119:1605-1613
1. The biosynthesis of noradrenaline following sympathetic nerve activation was investigated in rat atria. In particular the time course of noradrenaline synthesis changes, the relationship of changes in synthesis to transmitter release and the possi
Publikováno v:
British Journal of Pharmacology. 119:1411-1421
1. The pathological features of Gram-positive shock can be mimicked by the co-administration of two cell wall components of Staphylococcus aureus, namely lipoteichoic acid (LTA) and peptidoglycan (PepG). This is associated with the expression of the
Autor:
Emmanuel Naline, Susana Chuliá, Charles Advenier, M. Pilar D'ocon, M. Antonia Noguera, Joelle Moreau, M. Dolores Ivorra
Publikováno v:
British Journal of Pharmacology. 119:1305-1312
1. The cardiovascular activity of S-(+)-boldine, an aporphine alkaloid structurally related to papaverine, was determined. The work includes functional studies on guinea-pig isolated aorta contracted with noradrenaline, caffeine, KCl or Ca2+, and on
Publikováno v:
British Journal of Pharmacology. 119:1470-1476
1. A comparison of the effects of dietary and genetically-induced hypercholesterolaemia on the vasodilator and antiaggregatory capacity of the endothelium was made in rabbit isolated subclavian artery rings. 2. Dietary-induced hypercholesterolaemia i
Publikováno v:
British Journal of Pharmacology. 119:1463-1469
1. Adenosine (ADO) is a potent negative chronotropic agent in the mammalian myocardium. We have used single myocytes from rabbit sino-atrial node (SAN) to examine whether nitric oxide (NO) is a significant mediator of the effects of ADO on the pacema
Autor:
Andrea L. Peres, Jan D. Huizinga, Rosa Espinosa-Luna, Carlos Barajas-López, Vladimir Gerzanich, Stephen M. Collins
Publikováno v:
British Journal of Pharmacology. 119:1541-1548
1. Whole-cell and outside-out patch clamp recordings were used to characterize the physiological and pharmacological properties of the P2x-purinoceptors of myenteric neurones from the guinea-pig ileum. 2. Adenosine 5'-triphosphate (ATP) and analogues
Publikováno v:
British Journal of Pharmacology. 119:1525-1532
1. Primary afferent neurones releasing the vasodilator, calcitonin gene-related peptide, mediate the gastric hyperaemic response to acid back-diffusion. The tachykinins neurokinin A (NKA) and substance P (SP) are located in the same neurones and are