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Publikováno v:
British Journal of Pharmacology. 131:569-577
Acetylcholine (ACh) is an important neuromodulator of cardiac function that is released upon stimulation of the vagus nerve. Despite numerous reports on activation of IKACh by acetylcholine in cardiomyocytes, it has yet to be demonstrated what role t
Autor:
W. C. Bowman, M. J. Rand
Publikováno v:
British Journal of Pharmacology. 120:228-247
The effects of the triethyl analogue of choline (triethyl 2-hydroxyethyl ammonium) on muscular activity have been studied in conscious rabbits, chicks, dogs and a cat. The contractions of the tibialis anticus and soleus muscles of cats under chloralo
Publikováno v:
British Journal of Pharmacology. 120:494-503
1 A cascade superfusion technique has been developed for the differential bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) released from porcine aortic endothelial cells cultured on microcarriers, packed into a column and perfu
Publikováno v:
British Journal of Pharmacology. 119:1470-1476
1. A comparison of the effects of dietary and genetically-induced hypercholesterolaemia on the vasodilator and antiaggregatory capacity of the endothelium was made in rabbit isolated subclavian artery rings. 2. Dietary-induced hypercholesterolaemia i
Publikováno v:
British Journal of Pharmacology. 119:1463-1469
1. Adenosine (ADO) is a potent negative chronotropic agent in the mammalian myocardium. We have used single myocytes from rabbit sino-atrial node (SAN) to examine whether nitric oxide (NO) is a significant mediator of the effects of ADO on the pacema
Autor:
Shigehiro Hayashi, Masaaki Kimura, Tsutomu Bandoh, Hironobu Mitani, Tetsuya Totsuka, Junji Ishikawa
Publikováno v:
British Journal of Pharmacology. 119:1269-1275
1. The effects of fluvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the vascular angiotensin converting enzyme (ACE) activity in hyperlipidaemic rabbits were compared with those of enalapril, an ACE inhibitor.
Publikováno v:
British Journal of Pharmacology. 119:91-98
1. Isolated tracheae of newborn rabbits were incubated in vitro and the outflow of 5-hydroxytryptamine (5-HT) was determined by h.p.l.c. with electrochemical detection. Evidence has previously been provided that this 5-HT outflow derives from neuroen
Autor:
Chun Guang Li, Michael J. Rand
Publikováno v:
British Journal of Pharmacology. 118:57-62
1. The effects of 7-ethoxyresorufin (7-ER), which is a substrate for and competitive inhibitor of cytochrome P450, were studied on responses to nitric oxide (NO), the NO donors sodium nitroprusside (SNP) and glyceryl trinitrate (GTN), acetylcholine-i
Autor:
Mao-Tsun Lin, Jju-Home Lin
Publikováno v:
British Journal of Pharmacology. 118:179-185
1. Fever was induced in rabbits by administration of Escherichia coli endotoxin (lipopolysaccharide; LPS; 0.001-10 micrograms) into the organum vasculosum laminae terminalis (OVLT). Deep body temperature was evaluated over a period of 7 h. 2. The LPS
Publikováno v:
British Journal of Pharmacology. 117:1302-1308
1. The role of membrane hyperpolarization on agonist-induced contraction was investigated in intact and alpha-toxin-skinned smooth muscles of rabbit mesenteric artery by use of the ATP-sensitive K+ channel opener, (-)-(3S,4R)-4-(N-acetyl-N-hydroxyami