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Publikováno v:
British Journal of Pharmacology. 157:1463-1473
BACKGROUND AND PURPOSE\ud \ud As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of the bladder outflow region, this study investigates the possible release of ATP or related purines in response to electrical field stimulation (EFS
Autor:
C. M. Kurz, Urszula Baranowska, Manfred Göthert, Barbara Malinowska, Eberhard Schlicker, S Łupiński
Publikováno v:
British Journal of Pharmacology. 157:1474-1482
Background and purpose: We examined whether cannabinoid CB1 and histamine H3 receptors resemble α2-adrenoceptors in that their presynaptically mediated cardiovascular effects are less marked in urethane- than in pentobarbitone-anaesthetized pithed r
Publikováno v:
British Journal of Pharmacology. 123:122-128
By using the sucrose gap technique, we have investigated the effect of the metabolically stable P2Y receptor agonist, adenosine 5′-O-2-thiodiphosphate (ADPβS), on the membrane potential and tension in the circular muscle of the guinea-pig proximal
Publikováno v:
British Journal of Pharmacology. 120:707-713
1. We investigated the contribution of nitric oxide (NO) to inhibitory neuromuscular transmission in murine proximal colon and the possibility that citrulline is recycled to arginine to maintain the supply of substrate for NO synthesis. 2. Intracellu
Autor:
Stavros Selemidis, T.M. Cocks
Publikováno v:
British Journal of Pharmacology. 120:662-666
1. Responses to electrical field stimulation (EFS; 0.5-10 Hz, 0.2 ms duration, supramaximal voltage for 20 s) of non-adrenergic, non-cholinergic, (NANC) nerves were obtained in preparations of rat anococcygeus pre-contracted with titrated concentrati
Publikováno v:
British Journal of Pharmacology. 119:1605-1613
1. The biosynthesis of noradrenaline following sympathetic nerve activation was investigated in rat atria. In particular the time course of noradrenaline synthesis changes, the relationship of changes in synthesis to transmitter release and the possi
Autor:
Michael A. Moskowitz, Xian-Jie Yu
Publikováno v:
British Journal of Pharmacology. 119:229-232
1. The effects of neuropeptide Y (NPY) receptor agonists (administered intravenously) were examined on plasma protein ([125I]-bovine serum albumin) leakage within dura mater evoked by unilateral trigeminal ganglion stimulation (0.6 mA, 5 ms, 5 Hz, 5
Autor:
Elliot Lilley, Alan Gibson
Publikováno v:
Scopus-Elsevier
1. The potential protective effect of several antioxidants [Cu/Zn superoxide dismutase (Cu/Zn SOD), ascorbate, reduced glutathione (GSH), and alpha-tocopherol (alpha-TOC)] on relaxations of the mouse anococcygeus muscle to nitric oxide (NO; 15 microM
Autor:
Heinz Kilbinger, K. Hebeiss
Publikováno v:
British Journal of Pharmacology. 118:2073-2078
1. The effects of the nitric oxide (NO) donors, 3-morpholino-sydnonimine (SIN-1), S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside on basal and electrically evoked release of [3H]-acetylcholine were studied in myenteric plexus longitud
Autor:
Sandro Giuliani, Carlo Alberto Maggi
Publikováno v:
British Journal of Pharmacology. 118:1262-1268
1. In the progress of experiments aimed at evaluating the role of tachykinins as enteric nonadrenergic noncholinergic (NANC) transmitters, we noted that certain tachykinin receptor antagonists produce a relaxation of circular muscle strips in the rat