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Publikováno v:
British Journal of Pharmacology. 113:1088-1092
1. The aim of the present study was to compare the biological activity of S-nitroso-L-cysteine (CYSNO), S-nitrosoglutathione (GSNO), S-nitroso-N-acetyl-D,L-penicillamine (SNAP) and hydroxylamine to that of nitric oxide (NO) and a vascular relaxing fa
Autor:
Laurent Monassier, Eduardo Tibiriçá, Roegel Jc, Bertrand Mettauer, Pascal Bousquet, Josiane Feldman
Publikováno v:
British Journal of Pharmacology. 111:1347-1354
1. The purpose of this study was to investigate further the role of the excitatory amino acid (EAA) system of neurotransmission, particularly of the NMDA receptor, in the central regulation of cardiac function. 2. Electrical stimulation of the parave
Publikováno v:
British Journal of Pharmacology. 110:1544-1550
1. Glutamate inhibits the electrically evoked release of noradrenaline in rabbit brain cortex slices; the inhibition is mediated by adenyl compounds, presumably adenosine. The aim of the present study was to identify the receptors involved in this in
Autor:
E. Gautier, S.Z. Langer, Hans Schoemaker, Philippe Manoury, Peter E. Hicks, F Lefèvre-Borg, J. Lechaire, F. Pierre, S.E. O'Connor, C. Pimoule
Publikováno v:
British Journal of Pharmacology. 109:1282-1289
1. Phenylephrine-induced contractions of rabbit isolated trigone and urethra were antagonized in a competitive manner by alfuzosin (pA2 7.44 and 7.30, respectively) and prazosin. 2. The characteristics of [3H]-prazosin binding to human prostatic aden
Publikováno v:
British Journal of Pharmacology. 109:1008-1013
1. We have used selective tachykinin receptor agonists and antagonists to investigate the nature of the receptors mediating responses to endogenous and exogenous tachykinins in the rabbit iris sphincter preparation in vitro. 2. The NK1-selective agon
Publikováno v:
British Journal of Pharmacology. 105:347-354
1. The roles of autofeedback and neuronal uptake in neurotransmission produced by electrical field stimulation in several rabbit isolated blood vessels were examined. 2. Blocking drugs were used to separate the possible purinergic and noradrenergic c
Autor:
Jane E. Nally, T.C. Muir
Publikováno v:
British Journal of Pharmacology. 105:367-375
1. Electrical and mechanical responses to field stimulation (1-64 Hz, 0.5 ms supramaximal voltage) were recorded simultaneously in the rabbit saphenous artery. The electrical response consisted entirely of excitatory junction potentials (e.j.ps) whic
Publikováno v:
British journal of pharmacology. 120(4)
1 Nitric oxide (NO) has been suggested as a gastrointestinal neurotransmitter, mediating the gastric receptive relaxation and the relaxation in the peristaltic reflex. The aim of the present study was to measure nerve-induced NO formation in vivo in
Publikováno v:
British journal of pharmacology. 115(7)
1. Isolated preparations of rabbit anococcygeus muscle were exposed to electrical field stimulation (EFS; 50V, 0.3 ms duration, 0.08-40 Hz) for periods of 1-60 s (short-term EFS) or 10 min-2 h (long-term EFS). 2. Both short- and long-term EFS caused
Publikováno v:
British journal of pharmacology. 111(1)
1. Exogenous tachykinins modulate cholinergic neurotransmission in rabbit and guinea-pig airways. We have investigated the effect of selective tachykinin receptor agonists and antagonists on cholinergic neurotransmission evoked by electrical field st