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Autor:
Sandro Giuliani, Carlo Alberto Maggi
Publikováno v:
British Journal of Pharmacology. 118:1262-1268
1. In the progress of experiments aimed at evaluating the role of tachykinins as enteric nonadrenergic noncholinergic (NANC) transmitters, we noted that certain tachykinin receptor antagonists produce a relaxation of circular muscle strips in the rat
Autor:
Roy G. Goldie, Peter J. Henry
Publikováno v:
British Journal of Pharmacology. 114:563-569
1. We have previously shown that endothelin-1-induced contraction of mouse isolated tracheal smooth muscle was mediated via both ETA and ETB receptors. In the current study, we have investigated endothelin-1-induced potentiation of cholinergic nerve-
Autor:
Yasuo Shimo, Shu-ichi Kojima
Publikováno v:
British Journal of Pharmacology. 114:73-76
1. In the presence of atropine (0.2 microM) and indomethacin (2 microM), the effects of 5-hydroxytryptamine (5-HT) have been studied on electrically-evoked, neurogenic contractions of the guinea-pig proximal colon in vitro. 2. 5-HT, at higher concent
Publikováno v:
British Journal of Pharmacology. 111:1321-1327
1. The effects of omega-conotoxin GVIA (omega-CgTX) and tetrodotoxin (TTX) on vasoconstrictions induced by acetylcholine (ACh) and nicotine were investigated and compared with those induced by periarterial electrical stimulation in the isolated and p
Publikováno v:
British Journal of Pharmacology. 104:263-269
1. The ability of cromakalim to modulate several different types of neuroeffector transmission has been assessed in guinea-pig isolated trachea. 2. In trachea treated with propranolol (10(-6) M) and indomethacin (2.8 x 10(-6) M), stimulation of the e
Publikováno v:
British Journal of Pharmacology. 103:1997-2003
1. The effects of electrical vagal stimulation on frequency-dependent gastric acid secretion were investigated in urethane-anaesthetized rats in vivo. 2. Stimulation at 4, 16 or 32 Hz was performed in rats treated with atropine (1 mg kg-1, i.v.), hex
Publikováno v:
British Journal of Pharmacology. 101:1011-1015
1. Descending inhibition in the proximal and distal portions of rat colon was studied separately, in vitro. 2. In the proximal colon, localized distension with a small balloon caused three types of response (contraction; relaxation; relaxation, then
Autor:
Helen M. Cox, Alan W. Cuthbert
Publikováno v:
British Journal of Pharmacology. 101:247-252
1. The effects of neuropeptide Y (NPY) and a range of C terminal fragments were investigated both on basal short circuit current (s.c.c.) and electrical field stimulated responses in voltage clamped preparations in rat jejunal mucosa. 2. Most of the
Autor:
A. Surprenant, S. Vanner
Publikováno v:
British Journal of Pharmacology. 99:840-844
1. Intracellular recordings were made from neurones of the guinea-pig submucosal plexus. The effects of several 5-hydroxytryptamine3 (5-HT3) receptor antagonists on depolarizations produced by ionophoretic application of 5-HT and acetylcholine, as we
Autor:
Y. M. Van Maercke, M. Rampart, P.A. Pelckmans, T J Verbeuren, Guy E. Boeckxstaens, I. F. Ruytjens, A.G. Herman
Publikováno v:
British journal of pharmacology, 101(2), 460-464. Wiley-Blackwell
1. The inhibitory effects of gamma-aminobutyric acid (GABA), the GABAA receptor agonist homotaurine and the GABAB receptor agonist (+/-)-baclofen were investigated on circular muscle strips of the dog terminal ileum and ileocolonic junction. 2. In th