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Autor:
Andrew Nelsen, Kamel Boukais, Chabha Benyahia, Lucie H. Clapp, Dan Longrois, Gulsev Ozen, Salma Mani, Xavier Norel, Adam M. Silverstein, Richard Bayles, Yves Castier, Claire Danel, Hervé Mal
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: In patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE(2) and PGI(2) induce potent relaxati
Publikováno v:
British Journal of Pharmacology. 176:282-296
BACKGROUND AND PURPOSE: Abdominal aortic aneurysm (AAA) is a degenerative disease affecting human health, but there are no safe and effective medications for AAA therapy. Cycloastragenol (CAG), derived from Astragali Radix, has various pharmacologica
Autor:
Margaret R. MacLean, K Polland, Ian Morecroft, Alison Stirrat, David Alexander, Eliot H. Ohlstein, Stephen A. Douglas, Marie Gallagher
Publikováno v:
British Journal of Pharmacology. 130:201-204
Responses to human urotensin-II (hU-II) were investigated in human and rat pulmonary arteries. Rat pulmonary arteries: hU-II was a potent vasoconstrictor of main pulmonary arteries (2–3 mm i.d.) (pEC50, 8.55±0.08, n=21) and was ∼4 fold more pote
Autor:
Francesca Guidobono, Antonio Pecile, Chiara Ticozzi, Carmela Netti, Valeria Sibilia, Francesca Pagani
Publikováno v:
British Journal of Pharmacology. 120:581-586
1. The effect of amylin on gastric ulcers induced by oral administration of indomethacin (Indo, 20 mg kg-1 at a dosing volume of 5 ml) or ethanol 50% (EtOH, 1 ml/rat) was investigated in conscious rats. 2. Amylin given intracerebroventricularly (0.22
Publikováno v:
British Journal of Pharmacology. 118:1931-1938
1. The aims of the study were to assess the contribution of prostaglandins and nitric oxide (NO) to the effects of endothelin (ETs) and sarafotoxin 6c (SX6c) in perfused rat lungs. This was carried out by using indomethacin, a cyclo-oxygenase inhibit
Autor:
C. M. Herd, Mark Holbrook, A. Z. El-Hashim, Clive P. Page, S.M. Blake, Gerry Higgs, Neil Gozzard, B. Hughes
Publikováno v:
British Journal of Pharmacology. 118:1201-1208
1. The effects of the inhaled corticosteroid budesonide and a novel PDE 4 inhibitor CDP840 given systematically, were evaluated in a model of antigen-induced airway inflammation in the rabbit. 2. Adult litter-matched NZW rabbits (2.4-3.5 kg) immunise
Publikováno v:
British Journal of Pharmacology. 117:1277-1285
1. We investigated the characteristics of endothelin (ET)-induced contraction and changes in intracellular Ca2+ concentration ([Ca2+]i) using the fura-2-loaded and non-loaded rabbit iris dilator. ET-1 and ET-2 (3-100 nM) and ET-3 (30-100 nM) caused c
Publikováno v:
University of Western Australia
1. In the current study, the density and function of ETA and ETB receptors in mouse tracheal airway smooth muscle were determined over the time course of respiratory tract infection with influenza A/PR-8/34 virus. 2. Quantitative autoradiographic stu
Publikováno v:
British Journal of Pharmacology. 117:1059-1064
1. Injections of N-methyl-D-aspartate (NMDA) and quinolinic acid (Quin), agonists that activate NMDA receptors, into the rat nucleus basalis magnocellularis (nbM) produced a dose-related decrease in cholineacetyltransferase (ChAT) activity in the cer
Autor:
Carlos M. Villalón, Enrique Castillo, Francisco Javier López-Muñoz, Eduardo Ramírez-San Juan, José A. Terrón, Carlos Castillo
Publikováno v:
British Journal of Pharmacology. 116:2778-2784
1. 5-Hydroxytryptamine (5-HT) can produce vasodilatation or vasoconstriction of the canine external carotid bed depending upon the degree of carotid sympathetic tone. Hence, external carotid vasodilatation to 5-HT in dogs with intact sympathetic tone