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Publikováno v:
British Journal of Pharmacology. 129:1285-1288
The action of isoprenaline has been evaluated in an isolated, left atrial assay, from aged transgenic mice with cardiac-specific over-expression of the β2-adrenoceptor. In the assay, isoprenaline produced a negative inotropic concentration-response
Autor:
Wilhelm Schmitz, Frank U. Müller, Bettina Linck, Joachim Neumann, Jörg Knapp, Peter Boknik, Ute Vahlensieck
Publikováno v:
British Journal of Pharmacology. 119:545-550
1. The effect of the phosphatase inhibitor, cantharidin (3-300 microM) on force of contraction was studied in isolated electrically driven right ventricular trabeculae carneae from human myocardium. 2. The positive inotropic effect of cantharidin sta
Publikováno v:
British Journal of Pharmacology. 119:505-510
1. In rat aortic rings contracted by phenylephrine, the relaxation induced by isoprenaline was partly inhibited by iberiotoxin, (ibTX), tetraethylammonium, 4-aminopyridine (4-AP) and 1,9-dideoxyforskolin, but not by glibenclamide. 2. In the presence
Publikováno v:
British Journal of Pharmacology. 119:471-478
1. In rat aortic rings precontracted with phenylephrine, the beta-adrenoceptor agonist isoprenaline (10 nM to 30 microM) produces greater relaxant effects in preparations with endothelium than in endothelium-denuded preparations. The aim of this stud
Autor:
Gert Folkerts, Frans P. Nijkamp, Peet G.F. Van de Loo, Ilse E.M. Dik, Gudarz Sadeghi-Hashjin, Paul A.J. Henricks
Publikováno v:
British Journal of Pharmacology. 118:466-470
1. Sodium nitroprusside (SNP) completely relaxed the guinea-pig isolated, perfused trachea in a concentration-dependent manner. Although SNP was less potent by about 2 orders of magnitude, its maximal effect was 25% higher compared to isoprenaline. 2
Autor:
Mabayoje A. Oriowo
Publikováno v:
British Journal of Pharmacology. 113:699-702
1. The possible existence of atypical beta-adrenoceptors in vascular smooth muscle of the rat common carotid artery was examined in this study. 2. Isoprenaline produced concentration-dependent relaxation of noradrenaline (10(-7) M) precontracted ring
Publikováno v:
British Journal of Pharmacology. 113:1043-1049
1. The pharmacological actions of the beta-adrenoceptor antagonists, celiprolol, bisoprolol and propranolol were investigated in human lung tissue by radioligand binding experiments as well as in human isolated bronchi by functional experiments in or
Publikováno v:
British Journal of Pharmacology. 106:813-818
1. We have studied the ability of some adrenergic neurone blocking agents to inhibit the tracheal relaxant actions of isoprenaline, theophylline and the potassium channel openers (KCOs) BRL 38227, pinacidil and RP 52891. 2. BRL 38227, isoprenaline, p
Publikováno v:
British Journal of Pharmacology. 106:556-562
1. Removal of the epithelium resulted in a threefold increase in guinea-pig tracheal sensitivity to histamine without increasing the maximal response. 2. Preincubation of epithelially-denuded guinea-pig tracheal smooth muscle with leukotriene E4 (LTE
Autor:
Adrian Tomkinson, David Raeburn
Publikováno v:
British journal of pharmacology. 118(8)
1. We have examined the effects of the isoenzyme-selective phosphodiesterase (PDE) inhibitors, vinpocetine (type 1), siguazodan (type 3), rolipram (type 4) and zaprinast (type 5) and the non-selective PDE inhibitor enprofylline on methacholine (MCh)