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Autor:
Janet Tillman, Roger J. Summers
Publikováno v:
British Journal of Pharmacology. 65:689-699
1. Cocaine (2 x 10(-6) M and 10(-5) M) produced 2 and 7 fold shifts to the left of the dose-response curve to (-)-noradrenaline recorded isotonically in isolated splenic capsular strips of the cat. 2. The same concentrations of cocaine also produced
Autor:
J.R.S. Hoult, Judith A. Phillips
Publikováno v:
British Journal of Pharmacology. 95:701-712
1. Sheets of muscle-stripped rat and rabbit colon with epithelium intact or removed were mounted in Ussing-type chambers for recording of transepithelial p.d., resistance and short circuit current (Isc), and measurement by radioimmunoassay (RIA) of t
Publikováno v:
British Journal of Pharmacology. 74:651-663
1 The ability of cyproheptadine (Cph) to inhibit membrane translocation of calcium in smooth muscle was investigated by studying the drug's action on contraction, electrical activity and calcium influx in the guinea-pig taenia coli.2 Cph >/= 10(-6)M
Autor:
Ming‐Sheng Zhang, Er‐Feng Zhou
Publikováno v:
British Journal of Pharmacology. 94:1184-1188
1. The effects of methylflavonolamine hydrochloride (4'-methyl-7-(2-hydroxy-3-isopropylamino-propoxy)-flavone hydrochloride, MFA) were investigated and compared with verapamil and papaverine on rabbit isolated aortic strips, which were contracted by
Autor:
Tsuyoshi Karashima
Publikováno v:
British Journal of Pharmacology. 73:867-877
1 Effects of pretreatment with isoprenaline (Isop) or noradrenaline (NA) and various ionic environments on the NA-induced or Isop-induced hyperpolarization of guinea-pig liver cells were investigated by means of a microelectrode technique. 2 NA (5.9
Publikováno v:
British Journal of Pharmacology. 92:835-841
1 The effects of quinine sulphate, tetramethylammonium chloride (TMA) and tetraethylammonium chloride (TEA) (all blockers of the Ca2+-activated K+ channels) on the relaxations induced by acetylcholine (ACh), calcium ionophore A23187 and sodium nitrit
Autor:
Jo R. Cunningham, M.J. Neal
Publikováno v:
British Journal of Pharmacology. 73:655-667
1 The mechanisms by which veratridine increases the release of gamma-aminobutyric acid (GABA) from brain slices have been studied.2 Exposure of superfused cerebro-cortical, nigral or cerebellar slices to veratridine (5 muM) or KCl (50 mM) caused larg
Autor:
David M. Paton
Publikováno v:
British Journal of Pharmacology. 49:614-627
1. The mechanism of efflux of (-)-[(3)H]-noradrenaline was examined in rabbit atria, which were pretreated with reserpine and pargyline.2. Between 40 and 100 min, efflux occurred predominantly from a single intraneuronal compartment.3. Efflux was rap
Autor:
A.R. Bichard, H.J. Little
Publikováno v:
British Journal of Pharmacology. 76:447-452
1 The effects on the high pressure neurological syndrome (HPNS) of drugs which facilitate gamma-aminobutyric acid (GABA) transmission were investigated. Threshold pressures for the onset of the behavioural signs of the HPNS in mice--tremors and convu
Autor:
Torben Johansen
Publikováno v:
Johansen, T 1979, ' Utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187 ', British Journal of Pharmacology, vol. 65, no. 1, pp. 103-9 .
The role of endogenous adenosine triphosphate (ATP) in histamine release from rat mast cells induced by the ionophore A23187 in vitro has been studied. 2 The amount of histamine released by calcium from rat mast cells primed with the ionophore A23187