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pro vyhledávání: ''
Autor:
Marek Toczek, Irena Kasacka, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Ewa Harasim-Symbor, Barbara Malinowska, Jolanta Weresa
Publikováno v:
British Journal of Pharmacology. 174:2114-2129
Background and Purpose Fatty acid amide hydrolase (FAAH) inhibitors are postulated to possess anti-hypertensive potential, because their acute injection decreases BP in spontaneously hypertensive rats (SHR), partly through normalization of cardiac co
Autor:
Tor Skomedal, Cam H.T. Nguyen, Silja Meier, Geir Christensen, Ivar Sjaastad, Øivind Ørstavik, Karina Hougen, J.-B. Osnes, Eirik Qvigstad, Lise Román Moltzau, Jan Magnus Aronsen, Finn Olav Levy
Publikováno v:
British Journal of Pharmacology. 170:366-379
Background and Purposes Myocardial C-type natriuretic peptide (CNP) levels are increased in heart failure. CNP can induce negative inotropic (NIR) and positive lusitropic responses (LR) in normal hearts, but its effects in failing hearts are not know
Autor:
Miguel Pérez-Aso, M.A. Noguera, Francesc Jiménez-Altayó, Vanessa Segura, S Estrada, Ivorra, Elisabet Vila, Pilar D'Ocon, JF Seller, Nicla Flacco
Publikováno v:
British Journal of Pharmacology. 169:413-425
Background and Purpose To analyse the relative contribution of β1-, β2- and β3-adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing the role of cAMP and/or NO/cGMP signalling pathways. Experimental Approach Rat m
Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy
Autor:
Mandy M Y Tse, Beshay N M Zordoky, Bruce D. Hammock, Hassan N. Althurwi, Ghada Abdelhamid, Ayman O.S. El-Kadi
Publikováno v:
British Journal of Pharmacology. 168:1794-1807
Background and Purpose We have previously shown that isoprenaline-induced cardiac hypertrophy causes significant changes in the expression of cytochromes P450 (CYP) and soluble epoxide hydrolase (sEH) genes. Therefore, it is important to examine whet
Publikováno v:
British Journal of Pharmacology. 127:895-902
1. Negative inotropic effects of several beta-adrenoceptor (betaAR) antagonists on electrically-stimulated right atria, left atria, right ventricles and left ventricular papillary muscles from reserpine-treated rats were used as a measure of their in
Publikováno v:
British Journal of Pharmacology. 124:1449-1454
1. Thapsigargin (TPG, 3 microM) and cyclopiazonic acid (CPA, 10 microM) slowly increased muscle tone in the guinea-pig isolated tracheal muscle. A large sustained contraction was produced when 2.4 mM Ca2+ was readmitted after 10 min exposure to Ca2+-
Publikováno v:
British Journal of Pharmacology. 122:158-164
1 The involvement of cyclic AMP-dependent protein kinase (PKA) and cyclic GMP-dependent protein kinase (PKG) in the effects of cyclic AMP-elevating agents on vascular smooth muscle relaxation, cyclic nucleotide dependent-protein kinase activities and
Publikováno v:
British Journal of Pharmacology. 121:1247-1254
1. The effects of dopamine on the L-type Ca2+ current (ICa,L) of both atrial and ventricular single myocytes and on the force of contraction of atrial trabeculae in rat heart were investigated. 2. Dopamine increased atrial ICa,L at concentrations hig
Autor:
Andrew P. Stork, Thomas M. Cocks
Publikováno v:
British Journal of Pharmacology. 113:1099-1104
1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation
Publikováno v:
British Journal of Pharmacology. 102:162-166
1. Basal release of endothelium-derived relaxing factor (EDRF) rendered endothelium-containing rings of rat aorta 4.7 fold less sensitive to the contractile actions of phenylephrine and depressed the maximum response when compared with endothelium-de