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Publikováno v:
British Journal of Pharmacology. 178:4316-4334
Existing pharmacotherapies for managing craving, a strong predictor of relapse to automated addictive behaviours, are limited in efficacy and characterised by increased health risks associated with their pharmacological profile. Preclinical studies h
Autor:
Giambattista Bonanno, Nadia Bertola, Giulia Frumento, Mandeep Kumar, T P Nhung Nguyen, Tiziana Bonifacino, Arianna Roberta Zerbo, Carola Torazza, Matilde Balbi, Maurizio Viale, Aldo Profumo, Sara Ferrando, Francesca Provenzano, Marco Milanese, Silvia Ravera
Publikováno v:
British Journal of Pharmacology
British journal of pharmacology 178(18), 3747-3764 (2021). doi:10.1111/bph.15515
British journal of pharmacology 178(18), 3747-3764 (2021). doi:10.1111/bph.15515
Background and Purpose The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic
Autor:
Vladimer Darsalia, Dimitra Karampatsi, Martin Larsson, Doortje Dekens, Gesine Paul, Thomas Nyström, Osama Elabi, Alexander Zabala, Ingrid Lovise Augestad, Cesare Patrone, Hiranya Pintana
Publikováno v:
British Journal of Pharmacology. 179:677-694
Glucagon-like peptide-1 (GLP-1) receptor activation decreases stroke risk in people with Type 2 diabetes (T2D), while animal studies have shown the efficacy of this strategy to counteract stroke-induced acute brain damage. However, whether GLP-1 rece
Publikováno v:
British Journal of Pharmacology. 178:3849-3863
As an agonist of the classical nuclear receptors, estrogen receptor-α and -β (NR3A1/2), estrogen has been assumed to inhibit the development of cardiovascular disease in premenopausal women. Indeed, reduced levels of estrogen after menopause are be
Autor:
Aleksandar Dobric, Ivan Bernardo, Ross Vlahos, Kurt Brassington, Stanley M H Chan, Simone N. De Luca, Steven Bozinovski, Chanelle Mastronardo, Kevin Mou, Stavros Selemidis, Huei Jiunn Seow
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) exposure. The p
Autor:
Terrance P. Snutch, Robert P. Bonin, Annemarie Dedek, Michael W. Salter, Erika K. Harding, Michael E. Hildebrand
Publikováno v:
British Journal of Pharmacology
Background and purpose T-type voltage-gated calcium channels are an emerging potential therapeutic target for neurological disorders including epilepsy and pain. Inhibition of T-type channels reduces the excitability of peripheral nociceptive sensory
Publikováno v:
British Journal of Pharmacology. 179:1525-1543
Intranasal oxytocin (OT) has been suggested as a putative adjunctive treatment for patients with schizophrenia and autism spectrum disorders (ASD). Here, we examine available evidence from trials investigating the effects of repeated administrations
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Ross Vlahos, Stanley M H Chan, Steven Bozinovski, Stavros Selemidis, Huei Jiunn Seow, Kurt Brassington, Aleksandar Dobric
Publikováno v:
British Journal of Pharmacology
Background and purpose It is well established that both smokers and patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning the onset and progression of co-morbid CVD are largely
Autor:
Paula Bueno, Chaitanya Chakravarthi Gali, Angel Cedazo-Minguez, Ahmed Saeed, Patricia Rodriguez-Rodriguez, Anna Sandebring-Matton, Carmen M Córdoba-Beldad, Valerio Leoni, Ute Panzenboeck, Cristina Parrado-Fernandez, Ingemar Björkhem
Publikováno v:
British Journal of Pharmacology
Background and Purpose: The cerebrospinal fluid (CSF)/plasma albumin ratio (QAlb) is believed to reflect the integrity of the blood–brain barrier (BBB). Recently, we reported that QAlb is lower in females. This may be important for uptake of neurot