Zobrazeno 1 - 10
of 1 294
pro vyhledávání: ''
Autor:
Patrick Trouillas, J. Javellaud, Václav Bazgier, Nicolas Picard, Pierre Marquet, Petra Čechová, Souleiman El Balkhi, Michal Otyepka, Franck Saint-Marcoux, Roland Lawson, Eliès Zarrouk
Publikováno v:
British Journal of Pharmacology. 180:829-842
BACKGROUND AND PURPOSE Opioids and benzodiazepines are frequently combined in medical as well as in non-medical contexts. At high doses, such combinations often result in serious health complications attributed to pharmacodynamics interactions. Here,
Autor:
Philip R. Holland, Peter J. Goadsby, Howard J. Loraine, Amanda J. Woodrooffe, Kirk W. Johnson, Paul R. Murdock, Marta Vila-Pueyo, Keith Page
Publikováno v:
British Journal of Pharmacology. 179:358-370
BACKGROUND AND PURPOSE Lasmiditan is a novel selective 5-HT1F receptor agonist, recently approved for acute treatment of migraine. 5-HT1F receptors are widely expressed in the CNS and trigeminovascular system. Here, we have explored the therapeutic e
Publikováno v:
British Journal of Pharmacology. 179:3-22
Epilepsy is a common neurological disorder characterized by repeated and spontaneous epileptic seizures and is not well controlled by current medication. Traditional theory suggests that epilepsy results from an imbalance of excitatory glutamate neur
Autor:
Jun Liu, Sun Li, Liang Dai, Haoliang Yuan, Xiaoan Wen, Liu Liu, Caiping Chen, Sui Qibang, Yanping You, Pan Yanhong, Hongbin Sun
Publikováno v:
British Journal of Pharmacology. 178:4907-4922
BACKGROUND AND PURPOSE Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing of cytosolic DNA to initiate dsDNA-driven immune
Autor:
Jin-Zi Ji, Peng-Xin Ge, Qiong-Yu Mi, Ting Zhu, Ting Tai, Hong-Guang Xie, Li-Ping Jiang, Yi-Fei Li
Publikováno v:
British Journal of Pharmacology. 179:46-64
Background and purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic
Publikováno v:
British Journal of Pharmacology. 178:4501-4517
BACKGROUND AND PURPOSE The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whet
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide
Autor:
Abdiwahab Shidane Ibrahim, Gianmichele Massimo, Clement Lau, Federica Filomena, Jianmin Chen, Alexander Jozua Pedro Hamers, James C. Moon, Lorna C. Gee, Vikas Kapil, Krishnaraj S. Rathod, Daniel Fernandes, Ajay Gupta, Amrita Ahluwalia, Gani Nuredini, Rayomand S. Khambata, C. Primus
Publikováno v:
British Journal of Pharmacology. 179:4757-4777
BACKGROUND AND PURPOSE NO is a vasodilator and independent modulator of cardiac remodelling. Commonly, in cardiac disease (e.g., heart failure), endothelial dysfunction (synonymous with NO deficiency) has been implicated in increased BP, cardiac hype
Publikováno v:
British Journal of Pharmacology. 178:4005-4025
Background and purpose Neuropathic pain places a devastating health burden, with effective therapies or drugs being scarce. We aimed to investigate the potential antiallodynic and antihyperalgesic effects of apigenin, a natural flavonoid with monoami
Autor:
Xiao Hu, Hui Ding, Su-Ying Cui, Yu Qin, Nurhumar Kurban, Yong-He Zhang, Hui-Ling Zhao, Xiang-Yu Cui, Yu-Tong Liu
Publikováno v:
British Journal of Pharmacology. 178:3696-3707
Background and purpose Mineralocorticoid receptors (MRs), glucocorticoid receptors (GRs) and corticotropin-releasing factor (CRF) in the paraventricular nucleus of hypothalamus (PVN) are involved in the response to stress. The present study investiga
Autor:
Aleksandar Dobric, Ivan Bernardo, Ross Vlahos, Kurt Brassington, Stanley M H Chan, Simone N. De Luca, Steven Bozinovski, Chanelle Mastronardo, Kevin Mou, Stavros Selemidis, Huei Jiunn Seow
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type of muscle dysfunction may be a direct consequence of oxidative insults evoked by cigarette smoke (CS) exposure. The p