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Publikováno v:
British Journal of Pharmacology. 120:420-425
1 The depressor responses to histamine, in anaesthetized cats and dogs, have been shown to involve both histamine H1- and H2-receptors. 2 In both species, histamine caused dose-dependent falls in blood pressure. The dose-response curve could be displ
Publikováno v:
British Journal of Pharmacology. 119:1619-1627
1. Male, Long Evans rats were instrumented chronically with pulsed Doppler probes and intravascular catheters to allow assessment of regional haemodynamic changes during i.v. infusion of lipopolysaccharide (LPS, 150 micrograms kg-1 h-1). 2. In the pr
Publikováno v:
British Journal of Pharmacology. 119:1665-1671
1. Recently, we developed a murine model to investigate toluene diisocyanate (%DI)-induced occupational asthma. After skin-sensitization and intranasal challenge with TDI (1%) mice exhibited tracheal hyperreactivity 24 h after the challenge. 2. The a
Autor:
Jari-Petteri Tolvanen, Mika Kähönen, Ilkka Pörsti, Kirsimarja Sallinen, Xiumin Wu, Heikki Mäkynen, Anu Pekki
Publikováno v:
British Journal of Pharmacology. 119:1137-1144
1. It has recently been suggested that therapy with beta-adrenoceptor blockers reduces peripheral arterial resistance via enhanced vascular dilatation. Therefore, we studied the effects of celiprolol, which is a specific beta 1-antagonist that has a
Autor:
Hartmut Ruetten, Christoph Thiemermann
Publikováno v:
British Journal of Pharmacology. 119:479-486
1. We investigated the effects of the selective endothelin (ET)A receptor antagonist BQ-485 and the selective ETB receptor antagonist BQ-788 on circulatory failure, multiple organ dysfunction syndrome (MODS) and the alterations in acid base balance c
Publikováno v:
British Journal of Pharmacology. 118:2085-2098
1. The heart of several species including man contains atypical beta-adrenoceptors, in addition to coexisting beta 1- and beta 2-adrenoceptors. We now asked the question whether or not the third cardiac beta-adrenoceptor is identical to the putative
Publikováno v:
British Journal of Pharmacology. 118:1925-1930
1. The role of endogenous bradykinin in mean arterial blood pressure (BP) homeostasis was studied in spontaneously hypertensive (SHR) and normotensive (WKY) rats by the use of a bradykinin B2-receptor antagonist (BKant; Hoe 140, 11.6 micrograms kg-1)
Autor:
Renato S.B. Cordeiro, Patrícia M.R. e Silva, Christianne Bandeira-Melo, Yajaira Singh, Marco A. Martins
Publikováno v:
British Journal of Pharmacology. 118:2192-2198
1. Recent evidence has implicated eosinophils in the inhibition of allergen-induced rat pleurisy, but the mechanism of this negative modulation is not completely understood. This study was undertaken in order to define the potential role of prostagla
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
1. The effects of the selective and potent novel platelet-activating factor (PAF) antagonist, UR-12633 (1-(3,3-diphenylpropionyl)-4-(3-pyridylcyanomethyl)piperidin e) on several markers of endotoxic shock syndrome were evaluated in rats and mice. 2.
Autor:
C. M. Herd, Mark Holbrook, A. Z. El-Hashim, Clive P. Page, S.M. Blake, Gerry Higgs, Neil Gozzard, B. Hughes
Publikováno v:
British Journal of Pharmacology. 118:1201-1208
1. The effects of the inhaled corticosteroid budesonide and a novel PDE 4 inhibitor CDP840 given systematically, were evaluated in a model of antigen-induced airway inflammation in the rabbit. 2. Adult litter-matched NZW rabbits (2.4-3.5 kg) immunise