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Autor:
Takio Ohka, Kouichi Nishi, Masayuki Mizuguchi, Tokunao Amemiya, Tamotsu Matsuda, Masaki Fujimura
Publikováno v:
British Journal of Pharmacology. 117:443-448
1. In this study, the role of neuropeptides in antigen-induced bronchoconstriction and bronchial responsiveness in guinea-pigs was evaluated by use of phosphoramidon, the inhibitor of neutral endopeptidases (NEP), the NK1 receptor antagonist, FK888,
Publikováno v:
British Journal of Pharmacology. 116:1589-1594
1. Relaxin (RLX) is a multifunctional hormone which, besides its role in pregnancy and parturition, has also been shown to influence the cardiovascular system. In this study, we investigated the effect of RLX on coronary flow of rat and guinea-pig he
Publikováno v:
British Journal of Pharmacology. 115:629-635
1. Two polydeoxyribonucleotides, produced by the controlled hydrolysis of DNA of mammalian lung (defibrotide and its lower molecular weight fraction, P.O. 085 DV), were studied for their ability to modify the release of nitrite and the coronary flow
Publikováno v:
British Journal of Pharmacology. 114:1206-1210
1 This study was undertaken to investigate whether, after a brief exposure of guinea-pig isolated ileum and rabbit jejunum to bremazocine, a κ-opioid agonist also possessing antagonist activity at μ-opioid receptors, the addition of opioid antagoni
Publikováno v:
British Journal of Pharmacology. 114:203-209
1 The mechanisms of action of platelet activating factor (PAF) in the bronchial and cardiovascular systems have not yet been fully elucidated. In order to characterize better and to ascertain whether the effects of PAF in both these systems may be as
Autor:
Donald C. Bolser, Sandra O'Reilly, Robert W. Egan, Richard W. Chapman, Frances C. DeGennaro, John A. Hey, William Kreutner
Publikováno v:
British Journal of Pharmacology. 113:1344-1348
1 The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of action of these GABA-B receptor agonists to inhibit the c
Publikováno v:
British Journal of Pharmacology. 112:795-800
1. The antitussive effects of moguisteine have been compared with codeine in several experimental models of cough in guinea-pigs and dogs. 2. Moguisteine and codeine dose-dependently (respective ED50 values are given in parentheses) inhibited cough i
Publikováno v:
British Journal of Pharmacology. 110:1381-1386
1. The effect of rapamycin (0.001 to 5 mg kg-1) on the increased leukocyte counts in bronchoalveolar lavage (BAL) fluid and hyperreactivity of isolated bronchial strips to histamine and acetylcholine (ACh) was studied following the intravenous inject
Publikováno v:
British Journal of Pharmacology. 109:1133-1139
1. BRL 55834, a novel potassium channel activator, has been compared with levcromakalim (BRL 38227) for its relaxant effects in vivo on the airways and vasculature of the guinea-pig and rat. 2. When administered intravenously 2 min prior to challenge
Publikováno v:
British Journal of Pharmacology. 108:1083-1093
1. Guinea-pig tracheal contractions by histamine and by the cholinoceptor agonist, arecoline, are significantly enhanced (30% and 20%, respectively), 96 h after intra-tracheal inoculation with Parainfluenza-3 (PI-3) virus. 2. The airway hyperresponsi