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Publikováno v:
British Journal of Pharmacology. 157:1463-1473
BACKGROUND AND PURPOSE\ud \ud As adenosine 5'-triphosphate (ATP) is one of the inhibitory mediators of the bladder outflow region, this study investigates the possible release of ATP or related purines in response to electrical field stimulation (EFS
Autor:
C. M. Kurz, Urszula Baranowska, Manfred Göthert, Barbara Malinowska, Eberhard Schlicker, S Łupiński
Publikováno v:
British Journal of Pharmacology. 157:1474-1482
Background and purpose: We examined whether cannabinoid CB1 and histamine H3 receptors resemble α2-adrenoceptors in that their presynaptically mediated cardiovascular effects are less marked in urethane- than in pentobarbitone-anaesthetized pithed r
Autor:
Jackie Elliott, John R. Traynor
Publikováno v:
British Journal of Pharmacology. 114:1064-1068
1. There is evidence from in vivo studies for an interaction of mu- and delta-opioid ligands. In the present work this concept has been investigated using the mouse vas deferens and guinea-pig ileum myenteric plexus-longitudinal preparations. 2. In f
Publikováno v:
British Journal of Pharmacology. 113:282-288
1. The effect of the nitric oxide synthase (NOS) inhibitor, 7-nitro indazole (7-NI), on sympathetic and purinergic neurotransmission in the rat isolated vas deferens preparation has been studied. 2. 7-NI (50-200 microM) caused a dose- and frequency-d
Autor:
E. Gautier, S.Z. Langer, Hans Schoemaker, Philippe Manoury, Peter E. Hicks, F Lefèvre-Borg, J. Lechaire, F. Pierre, S.E. O'Connor, C. Pimoule
Publikováno v:
British Journal of Pharmacology. 109:1282-1289
1. Phenylephrine-induced contractions of rabbit isolated trigone and urethra were antagonized in a competitive manner by alfuzosin (pA2 7.44 and 7.30, respectively) and prazosin. 2. The characteristics of [3H]-prazosin binding to human prostatic aden
Publikováno v:
British Journal of Pharmacology. 109:1008-1013
1. We have used selective tachykinin receptor agonists and antagonists to investigate the nature of the receptors mediating responses to endogenous and exogenous tachykinins in the rabbit iris sphincter preparation in vitro. 2. The NK1-selective agon
Autor:
Pierre Blier, Claude Bouchard
Publikováno v:
British Journal of Pharmacology. 108:13-22
1. The aims of the present study were to confirm the modulation by 5-HT3 receptors of the electrically evoked release of tritium from slices preloaded with [3H]-5-HT of guinea-pig frontal cortex, hippocampus and hypothalamus, and to assess their func
Publikováno v:
British Journal of Pharmacology. 107:347-351
1. The effect of (R)-alpha-methylhistamine, a selective H3-histamine receptor agonist, was examined on the neurogenic hypertension and tachycardia that is induced by stimulation of areas in the medulla oblongata of guinea-pigs. Electrical medullary s
Autor:
B. Nickel, H. Gozlan, Manfred Göthert, Eberhard Schlicker, U. Werner, L Szelenyi, Michel Hamon
Publikováno v:
British Journal of Pharmacology. 105:732-738
1. The purpose of the present study was to relate the effects of the novel drug, anpirtoline, on 5-hydroxytryptamine (5-HT) receptor subtypes to its antinociceptive and antidepressant-like actions in rodents. 2. Binding assays with rat brain membrane
Publikováno v:
British Journal of Pharmacology. 105:516-520
1. The effect of adenosine triphosphate (ATP) and its stable analogues, alpha, beta-methylene-ATP and beta, gamma-methylene-ATP, on the efferent function of capsaicin-sensitive non-adrenergic, non-cholinergic (NANC) nerves was tested in guinea-pig is