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Publikováno v:
British Journal of Pharmacology
Background and purpose FK506 and rapamycin are modulators of FK-binding proteins (FKBP) that are used to suppress immune function after organ and hematopoietic stem cell transplantations. The drugs share the unwanted side-effect of evoking hypertensi
Autor:
Carlos Nascimento, Paulo Correia-de-Sá, M.A. Timóteo, Margarida Duarte-Araújo, M.T. Magalhães-Cardoso
Publikováno v:
British Journal of Pharmacology. 156:519-533
The relative contribution of distinct ecto-nucleotidases to the modulation of purinergic signalling may depend on differential tissue distribution and substrate preference.Extracellular ATP catabolism (assessed by high-performance liquid chromatograp
Publikováno v:
British Journal of Pharmacology. 151:332-340
Background and purpose: The small and intermediate conductance, Ca2+-sensitive K+ channels (SKCa and IKCa, respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IKCa and
Autor:
Kunio Nakahara, Teruo Oku, Noriaki Inamura, Masayuki Asano, Takayuki Inoue, Akira Katayama, Hiroe Sawai, Hiroshi Kayakiri, Chie Hatori, Yoshito Abe, Masakuni Okuhara, Tatsujiro Fujiwara, Yuki Sawada, Shigeki Satoh
Publikováno v:
British Journal of Pharmacology. 120:617-624
1. An orally active, nonpeptide bradykinin (BK) B2 receptor antagonist, FR173657 (E)-3-(6-acetamido-3-pyridyl)-N-[N-[2-4-dichloro-3-[(2-methyl-8-quinolin yl) oxymethyl]phenyl]-N-methylaminocarbonyl-methyl] acrylamide) has been identified. 2. This com
Publikováno v:
British Journal of Pharmacology. 120:695-701
1. The nature and cellular mechanisms that are responsible for endothelium-dependent relaxations resistant to indomethacin and NG-nitro-L-arginine methyl ester (L-NAME) were investigated in phenylephrine (PE) precontracted isolated carotid arteries f
Publikováno v:
British Journal of Pharmacology. 120:439-446
1. In rat mesenteric artery, acetylcholine (ACh) causes endothelium-dependent hyperpolarization by releasing endothelium-derived hyperpolarizing factor (EDHF). Recent evidence suggests that EDHF may be a cytochrome P450-derived arachidonic acid metab
Autor:
Emmanuel Naline, Susana Chuliá, Charles Advenier, M. Pilar D'ocon, M. Antonia Noguera, Joelle Moreau, M. Dolores Ivorra
Publikováno v:
British Journal of Pharmacology. 119:1305-1312
1. The cardiovascular activity of S-(+)-boldine, an aporphine alkaloid structurally related to papaverine, was determined. The work includes functional studies on guinea-pig isolated aorta contracted with noradrenaline, caffeine, KCl or Ca2+, and on
Autor:
Maria Grazia Giovannini, Marco Cecchi, Giancarlo Pepeu, R. Leurs, L. Bartolini, Patrizio Blandina, M. Giorgetti, H. Timmerman
Publikováno v:
British Journal of Pharmacology. 119:1656-1664
1. The effects of histamine and agents at histamine receptors on spontaneous and 100 mM K(+)-evoked release of acetylcholine, measured by microdialysis from the cortex of freely moving, rats, and on cognitive tests are described. 2. Local administrat
Autor:
Jari-Petteri Tolvanen, Mika Kähönen, Ilkka Pörsti, Kirsimarja Sallinen, Xiumin Wu, Heikki Mäkynen, Anu Pekki
Publikováno v:
British Journal of Pharmacology. 119:1137-1144
1. It has recently been suggested that therapy with beta-adrenoceptor blockers reduces peripheral arterial resistance via enhanced vascular dilatation. Therefore, we studied the effects of celiprolol, which is a specific beta 1-antagonist that has a
Publikováno v:
British Journal of Pharmacology. 119:891-898
1. This study examined the influence of respiratory tract infection with influenza A/PR-8/34 virus on endothelin receptor-mediated modulation of contraction induced by stimulation of cholinergic nerves in mouse isolated trachea. 2. The ETB receptor-s