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Autor:
W. C. Bowman, M. J. Rand
Publikováno v:
British Journal of Pharmacology. 120:228-247
The effects of the triethyl analogue of choline (triethyl 2-hydroxyethyl ammonium) on muscular activity have been studied in conscious rabbits, chicks, dogs and a cat. The contractions of the tibialis anticus and soleus muscles of cats under chloralo
Autor:
Heinz Kilbinger, K. Hebeiss
Publikováno v:
British Journal of Pharmacology. 118:2073-2078
1. The effects of the nitric oxide (NO) donors, 3-morpholino-sydnonimine (SIN-1), S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside on basal and electrically evoked release of [3H]-acetylcholine were studied in myenteric plexus longitud
Publikováno v:
British Journal of Pharmacology. 117:1413-1420
1. Previous studies have provided evidence that activation of beta-adrenoceptors on cholinergic nerve terminals can inhibit neurotransmission in the airways. However, in most cases, this conclusion has been based on indirect evidence obtained from me
Autor:
Shinichiro Kokubun, Minori Hashimoto
Publikováno v:
British Journal of Pharmacology. 115:636-640
1. The contribution of P2-purinoceptors to neurogenic contraction was investigated in rat urinary bladder smooth muscle by measurement of isotonic tension. 2. Contraction of rat urinary bladder smooth muscle induced by electrical stimulation was decr
Autor:
Roy G. Goldie, Peter J. Henry
Publikováno v:
British Journal of Pharmacology. 114:563-569
1. We have previously shown that endothelin-1-induced contraction of mouse isolated tracheal smooth muscle was mediated via both ETA and ETB receptors. In the current study, we have investigated endothelin-1-induced potentiation of cholinergic nerve-
Publikováno v:
British Journal of Pharmacology. 113:1183-1190
1. We characterized the tachykinin receptor(s) mediating 'sensory-efferent' neural control of release of 35SO4-labelled macromolecules (mucus) from ferret trachea in vitro in Ussing chambers using selective tachykinin antagonists. Secretion was induc
Autor:
M. A. Zar, Mahmoud M. Iravani
Publikováno v:
British Journal of Pharmacology. 113:95-102
1. Immunohistochemical and isolated organ bath techniques were used to detect the presence of neuropeptide Y (NPY) in the rat urinary bladder and to determine its effect on tone, spontaneous activity and contractile responses of the detrusor muscle t
Autor:
D. Spina, Roy G. Goldie
Publikováno v:
British Journal of Pharmacology. 112:895-900
1. The synthetic cationic polypeptide, poly-L-arginine (0.03-1 mg ml-1) induced concentration-dependent contraction of guinea-pig and rat isolated trachea. In guinea-pig isolated trachea, this response was attenuated in the presence of the muscarinic
Publikováno v:
British Journal of Pharmacology. 111:1321-1327
1. The effects of omega-conotoxin GVIA (omega-CgTX) and tetrodotoxin (TTX) on vasoconstrictions induced by acetylcholine (ACh) and nicotine were investigated and compared with those induced by periarterial electrical stimulation in the isolated and p
Publikováno v:
British Journal of Pharmacology. 110:833-839
1. The role of endogenous nitric oxide (NO) as a modulator of enteric neurotransmission was investigated in longitudinal muscle myenteric plexus (LMMP) preparations of guinea-pig isolated ileum. 2. In tissues previously incubated with [3H]-choline, e