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Autor:
Jin-Zi Ji, Peng-Xin Ge, Qiong-Yu Mi, Ting Zhu, Ting Tai, Hong-Guang Xie, Li-Ping Jiang, Yi-Fei Li
Publikováno v:
British Journal of Pharmacology. 179:46-64
Background and purpose Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic
Publikováno v:
British Journal of Pharmacology. 178:4501-4517
BACKGROUND AND PURPOSE The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whet
Autor:
Xiaofang Gao, Zuofeng Liu, Yu Wang, Minhui Li, Ping Li, Pengfan Qie, Dong Renhan, Xu Gaojie, Lijuan Su, Peng Jian, Bin Guang, Sisi Yu, Siyuan Liu, Huang Sheng, Jin Liu, Siqi Yu, Hu Wen, Tai Yang
Publikováno v:
British Journal of Pharmacology. 178:4741-4757
BACKGROUND AND PURPOSE Aberrant lipid metabolism is recognized as a key feature of cancer cells. Our initial research on MS-based analysis of lipids in a multiple myeloma (MM) cell line showed a significant accumulation of lipids in multiple myeloma
Autor:
Antonino Bongiovanni, Florent Auger, Sandrine Bergeron, Charlotte Laloux, Yaohua Chen, Camille Potey, Sophie Gautier, Régis Bordet, Aurélie Jonneaux, Clémence Leboullenger, Romain Barus, Meryem Tardivel
Publikováno v:
British Journal of Pharmacology. 178:1705-1721
BACKGROUND AND PURPOSES Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and
Autor:
Anne T. Nies, Elke Schaeffeler, Kathrin Klein, Kathleen M. Giacomini, Michel Eichelbaum, Matthias Schwab, Ute Hofmann, Claudia Neul, Stefan Winter
Publikováno v:
British Journal of Pharmacology. 178:1459-1474
Background and purpose The metabolic activity of cytochrome P450 (CYP) 2D6 is highly variable and CYP2D6 genotypes insufficiently explain the extensive and intermediate metabolic phenotypes, limiting the prediction of drug response plus adverse drug
Autor:
Limin Zhou, Jiajia Zhao, Long Hin Poon, Zi-wei Li, Kenneth K.W. To, Zhi-Xiu Lin, Yufeng Zhang, Jun Zhang, Yuanfeng Lyu, Zhong Zuo, Xiaoyu Yan
Publikováno v:
British Journal of Pharmacology. 178:582-599
Background and purpose Altered drug pharmacokinetics is a significant concern in non-alcoholic steatohepatitis (NASH) patients. Although high-fat high-cholesterol (HFHC) diet-induced NASH (HFHC-NASH) rats could simulate the typical dysregulation of c
Autor:
Huijun Sun, Kexin Liu, Jingjing Wu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Chong Wang, Xiaodong Ma, Yanna Zhu
Publikováno v:
Br J Pharmacol
Background and purpose Diclofenac is a widely used nonsteroidal anti-inflammatory drug. However, adverse effects in the kidney limit its clinical application. The present study was aimed to evaluate the potential effect of cilastatin on diclofenac-in
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Purine metabolism in mice and human differ in terms of uricase (Uox) activity as well as hypoxanthine phosphoribosyltransferase (HPRT) activity. The aim of this study was the establishment of high HPRT activity–Uox knockout
Autor:
Sirin A. Adham, Noura Al-Zeheimi
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Patients with locally advanced breast cancer usually receive third‐generation neoadjuvant chemotherapy (NAC). Although NAC treatment improved the overall survival, patients' response varies, some acquire resistance and other
Autor:
Ping Wang, Xiaojie Li, Yuanyuan Li, Boyu Liu, Boyi Liu, Chuan Wang, Chengyu Yin, Xiaoli Zheng, Yan Tai
Publikováno v:
Br J Pharmacol
Background and purpose Gout arthritis, which is provoked by monosodium urate (MSU) crystal accumulation in the joint and periarticular tissues, induces severe pain and affects quality of life of the patients. Eucalyptol (1,8-cineol), the principal co