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Publikováno v:
British Journal of Pharmacology. 179:2259-2274
BACKGROUND AND PURPOSE Inward rectifier potassium (KIR ) channels are key effectors of vasodilatation in neurovascular coupling (NVC). KIR channels expressed by cerebral endothelial cells (EC) have been confirmed essential modulators of NVC. Alzheime
Autor:
Bela Juhasz, Reka Szekeres, Árpád Kovács, Tician Wilisicz, Marcel Sieme, Zoltán Szilvássy, Anikó Pósa, Attila Tóth, Rudolf Gesztelyi, Zoltán Papp, Nazha Hamdani, Arnold Péter Ráduly, Melissa Herwig, Mariann Bombicz, Dániel Priksz, Rita Kiss, Balázs Varga, Judit Szilvássy, Nora Lampe
Publikováno v:
British Journal of Pharmacology. 179:2240-2258
BACKGROUND AND PURPOSE Small molecule BGP-15 has been reported to alleviate signs of heart failure and improve muscle function in murine models. Here, we investigated the acute and chronic effects of BGP-15 in a rabbit model of atherosclerotic cardio
Autor:
Marko Pregel, Jia Liu, Edward B. Stevens, Yiting Wang, David N. Sheppard, Walailak Jantarajit, Lishuang Cao, Allison P. Berg, Katy J. Sutcliffe
Publikováno v:
British Journal of Pharmacology. 179:1319-1337
BACKGROUND AND PURPOSE Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl- channels at the plasma membrane to en
Publikováno v:
British Journal of Pharmacology. 179:1125-1145
Fungal infections cause serious problems in many aspects of human life, in particular infections in immunocompromised patients present serious problems. Current anti-fungal antibiotics target various metabolic pathways, predominantly the cell wall or
Publikováno v:
BRITISH JOURNAL OF PHARMACOLOGY
Background and Purpose Voltage-gated sodium (Na-V) channels are expressed de novo in carcinomas where their activity promotes invasiveness. Breast and colon cancer cells express the neonatal splice variant of Na(V)1.5 (nNa(V)1.5), which has several a
Autor:
Laurent Plantier, Victor Tiroille, Damien Sizaret, Mélia Magnien, Sylvain Marchand-Adam, Madeleine Jaillet, Bruno Crestani, Coralie Mergault, Woodys Lenga Mabonda, Christelle Parent, Fanny Lisée
Publikováno v:
British Journal of Pharmacology. 179:125-140
BACKGROUND AND PURPOSE The Arp2/3 multiprotein complex regulates branched polymerisation of the actin cytoskeleton and may contribute to collagen synthesis and fibrogenesis in the lung. EXPERIMENTAL APPROACH Expression of Arp2/3 components was assess
Autor:
Xia-Qing Wu, Ying-Yong Zhao, Hua Miao, Xiao-Yong Yu, Yan-Long Zhao, Dan-Qian Chen, Wei Su, Yuan Zhang, Shougang Zhuang, Yan Guo, You-Quan Shang, Jia-Rong Mao, Jin Zhao, Nosratola D. Vaziri, Ming Gao, Huan-Qiao Zhang, Gang Cao, Yan-Ni Wang, Li Zhang, Shi-Xing Ma, Jin-Hua Zhang, Lin Chen
Publikováno v:
British Journal of Pharmacology. 179:103-124
BACKGROUND AND PURPOSE In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the molecular pathways targeted by me
Autor:
Rashid Giniatullin
Publikováno v:
British Journal of Pharmacology. 179:400-415
5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects. The raphe nuclei control nociceptive inputs by
Publikováno v:
British Journal of Pharmacology. 179:1808-1824
Advancing age is accompanied by significant remodelling of the immune system, termed immune senescence, and increased systemic inflammation, termed inflammageing, both of which contribute towards an increased risk of developing chronic diseases in ol
Autor:
Jun Liu, Sun Li, Liang Dai, Haoliang Yuan, Xiaoan Wen, Liu Liu, Caiping Chen, Sui Qibang, Yanping You, Pan Yanhong, Hongbin Sun
Publikováno v:
British Journal of Pharmacology. 178:4907-4922
BACKGROUND AND PURPOSE Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing of cytosolic DNA to initiate dsDNA-driven immune