Zobrazeno 81 - 90
of 5 903
pro vyhledávání: ''
Autor:
Jingjing Wu, Xiaodong Ma, Xiaokui Huo, Kexin Liu, Jiangnan Zhang, Huijun Sun, Zhihao Liu, Pengyuan Sun, Changyuan Wang, Qiang Meng, Chong Wang, Ran Bi
Publikováno v:
Br J Pharmacol
Background and purpose Catalpol, a water-soluble active ingredient isolated from Rehmannia glutinosa, exhibits multiple pharmacological activities. However, the mechanism(s) underlying protection against renal injury by catalpol remains unknown. Expe
Autor:
Yang Wang, Jian Zhang, Naiyu Hu, Yonglin Zhou, Jianfeng Wang, Shui Liu, Jiyun Li, Xuming Deng, Xiaodi Niu
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Bacteria producing New Delhi metallo‐β‐lactamase‐1 (NDM‐1) are an increasing clinical threat. NDM‐1 can inactivate almost all β‐lactams and is not sensitive to any existing β‐lactamase inhibitors. To identify
Autor:
Xianming Deng, Deng Zhou, Jie Jiang, Cai-Hong Yun, Li Li, Xin Huang, Xinrui Wu, Jingyi Su, Fu Gui, Yue Lu, Yunzhan Li, Guyue Chen, Ellen Weisberg, Yue-Ming Zhang, Zhixiang He, Siyang Song, Jianming Zhang
Publikováno v:
British Journal of Pharmacology. 176:4491-4509
Background and purpose Bruton's tyrosine kinase (BTK) plays a key role in B-cell receptor signalling by regulating cell proliferation and survival in various B-cell malignancies. Covalent low-MW BTK kinase inhibitors have shown impressive clinical ef
Publikováno v:
Br J Pharmacol
Background and purpose Signal transducer and activator of transcription 3 (STAT3) factor is associated with the development and progression of numerous types of human cancer. STAT3 activation is involved in metastasis. However, no STAT3 inhibitor has
Autor:
Xiaomeng Gao, Yanling Gong, Qiaojun He, Bo Yang, Ji Cao, Hong Zhu, Li Jiang, Xiaobing Chen, Meidan Ying
Publikováno v:
Br J Pharmacol
Stress granules (SGs) are primarily composed of mRNAs that stall at translation initiation and usually appear in the cytoplasm under unusual physiological or pathological conditions such as hypoxia, oxidative stress, and viral infection. Recent studi
Publikováno v:
British Journal of Pharmacology. 177:188-203
Author(s): Nguyen, Jacques D; Creehan, Kevin M; Kerr, Tony M; Taffe, Michael A | Abstract: Background and purposeAdolescents are regularly exposed to ∆9 -tetrahydrocannabinol (THC) via smoking and, more recently, vaping cannabis extracts. Growing l
Publikováno v:
British Journal of Pharmacology
Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long-term consumption of polyphenol-rich
Autor:
Ralf Weiskirchen
Publikováno v:
British Journal of Pharmacology. 178:378-380
Autor:
Koji Uchida, Kazuhiro Nishiyama, Yasu-Taka Azuma, Akiyuki Nishimura, Tomohiro Tanaka, Chiemi Toyama, Tomohiro Yamashita, Satoru Koyanagi, Yuko Ibuki, Takuro Numaga-Tomita, Naoya Matsunaga, Yasuyuki Fujimoto, Shigehiro Ohdo, Motohiro Nishida
Publikováno v:
Br J Pharmacol
Background and purpose Doxorubicin is a highly effective anticancer agent but eventually induces cardiotoxicity associated with increased production of ROS. We previously reported that a pathological protein interaction between TRPC3 channels and NAD
Publikováno v:
British Journal of Pharmacology
With an increasingly aging global population, the incidence of neurological diseases such as dementia is set to increase to unmanageable levels, yet there are currently only symptomatic therapies available for treatment. The mechanisms underlying the