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pro vyhledávání: ''
Autor:
Adam Kindelin, Andrew F. Ducruet, Kanchan Bhatia, Nasrul Hoda, Jennifer M. Eschbacher, Saif Ahmad, Chirayu D. Pandya, Rafay Chaudhary, Michael F. Waters, Alok Dwivedi, Qiang Liu
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Intravenous thrombolysis (IVT) after stroke enhances C3a generation, which may abrogate the benefits of reperfusion. The C3aR antagonist SB290157 is neuroprotective following transient but not permanent middle cerebral artery
Publikováno v:
British Journal of Pharmacology. 176:725-736
Background and purpose Acute insulin administration hyperpolarized, with concomitant decrease of firing rate, a subpopulation of arcuate proopiomelanocortin (POMC) and neuropeptide Y/agouti-related peptide cells. This rapid effect on cellular activit
Autor:
Rui Zhang, Chunmei Xu, Jianjun Dong, Tianyue Xie, Zhiwei Zou, Xiaojun Zhou, Xue Shen, Lin Liao
Publikováno v:
British Journal of Pharmacology. 176:478-490
Background and purpose Sulfonylureas (SUs) have been suggested to have an insulin-independent blood glucose-decreasing activity due to an extrapancreatic effect. However, a lack of adequate in vivo evidence makes this statement controversial. Here, w
Autor:
Amrita Banerjee, Udayan Ray, Smarajit Maiti, Arjun K. Ghosh, Madhusudan Das, Manuela Zaccolo, Subrata Kumar De, Suman Bhattacharya, Gausal A. Khan, Santanu Guha, Sarbashri Bank, Andreas Koschinski, Asru K. Sinha
Publikováno v:
British Journal of Pharmacology. 179:1284-1284
BACKGROUND AND PURPOSE Diabetes is common in tobacco-consuming individuals, hypoxia-encountering people, and post-menopausal women. The mechanism behind diabetes-associated vascular-dysfunction remains speculative. Dermcidin (DCD), an 11 kDa-protein
Autor:
Yoshimichi Ueda, Mutsumi Tsuchishima, Kaori Kinoshita, Mikihiro Tsutsumi, Ryuichi Kubota, Takashi Saito, Joseph George, Kazuaki Ozaki, Nobuhiko Hayashi
Publikováno v:
Br J Pharmacol
Background and purpose Hepatic steatosis may be associated with an increased γ-glutamyltransferase (γ-GT) levels. Ischaemia-reoxygenation (IR) injury causes several deleterious effects. We evaluated the protective effects of a selective inhibitor o
Autor:
Aliz Judit Ernyey, Csilla Pelyhe, Kornél Király, Tamás Baranyai, Attila Oláh, Zoltán Varga, Domokos Máthé, Péter Ferdinandy, Marek Jelemenský, Zoltán Giricz, Gábor Szénási, Tamás Radovits, István Gyertyán, Zsuzsanna Helyes, Csilla Terézia Nagy, Ferenc Kassai, Krisztián Szigeti, Sebestyén Tuza, Béla Merkely, Gábor Koncsos, Nóra Bukosza, Péter Hamar, Rainer Schulz, Zsófia Onódi
Publikováno v:
British Journal of Pharmacology. 175:3713-3726
Background and purpose Incidence and severity of obesity are increasing worldwide, however, efficient and safe pharmacological treatments are not yet available. Certain MAO inhibitors reduce body weight, although their effects on metabolic parameters
Autor:
Jin-Zi Ji, Tong-Tong Gu, Bei-Bei Huang, Yi-Fei Li, Hong-Guang Xie, Ting Zhu, Qiong-Yu Mi, Yu-Meng Jia, Ting Tai, Huan Zhou
Publikováno v:
Br J Pharmacol
Background and purpose Vicagrel is a novel promising antiplatelet drug designed for overcoming clopidogrel resistance. There is limited evidence indicating that exogenous IL-10 suppresses CYP3A4 activity in healthy subjects and that IL-10 knockout (K
Autor:
Fabiana Piscitelli, Yasmin Nasser, Ken Mackie, Marianna Nalli, Keith A. Sharkey, Mohammad Bashashati, V. Di Marzo, Catherine M. Keenan, Martin Storr, Winnie Ho
Publikováno v:
British Journal of Pharmacology. 172:3099-3111
Background and Purpose Endocannabinoids are a family of lipid mediators involved in the regulation of gastrointestinal (GI) motility. The expression, localization and function of their biosynthetic enzymes in the GI tract are not well understood. Her
Autor:
Hsu Cy, Sie Hw, Chen C, Y.K. Lai, Hung-Yuan Shih, Rohidas S. Sulake, Ching-Feng Weng, Huang Pk
Publikováno v:
British Journal of Pharmacology. 172:38-49
Background and Purpose The fungal product (+)-antroquinonol activates AMP kinase (AMPK) activity in cancer cell lines. The present study was conducted to examine whether chemically synthesized (+)-antroquinonol exhibited beneficial metabolic effects
Publikováno v:
British Journal of Pharmacology. 171:3246-3254
Background and Purpose Uncoupling protein-2 (UCP2) may regulate glucose-stimulated insulin secretion. The current study investigated the effects of berberine, an alkaloid found in many medicinal plants, on oxidative stress and insulin secretion throu