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pro vyhledávání: '"Tineke Casneuf"'
Autor:
Pierre W. Wijermans, Hong Xie, Peter M. Voorhees, Richard C. Frank, Robert Z. Orlowski, Brett Hall, Britte Kranenburg, Helgi van de Velde, Amrita Krishnan, Xiang Qin, Sonja Zweegman, Robert F. Manges, Sundar Jagannath, George Somlo, Tineke Casneuf, Suzanne Lentzsch, Sheeba K. Thomas, Pieter Sonneveld
Publikováno v:
British Journal of Haematology, 161(3), 357-366. Wiley-Blackwell Publishing Ltd
British Journal of Haematology, 161(3), 357-366. Wiley-Blackwell
Voorhees, P M, Manges, R F, Sonneveld, P, Jagannath, S, Somlo, G, Krishnan, A, Lentzsch, S, Frank, R C, Zweegman, S, Wijermans, P W, Orlowski, R Z, Kranenburg, B, Hall, B, Casneuf, T, Qin, X, te Velde, H, Xie, H & Thomas, S K 2013, ' A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma ', British Journal of Haematology, vol. 161, no. 3, pp. 357-366 . https://doi.org/10.1111/bjh.12266
British Journal of Haematology, 161(3), 357-366. Wiley-Blackwell
Voorhees, P M, Manges, R F, Sonneveld, P, Jagannath, S, Somlo, G, Krishnan, A, Lentzsch, S, Frank, R C, Zweegman, S, Wijermans, P W, Orlowski, R Z, Kranenburg, B, Hall, B, Casneuf, T, Qin, X, te Velde, H, Xie, H & Thomas, S K 2013, ' A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma ', British Journal of Haematology, vol. 161, no. 3, pp. 357-366 . https://doi.org/10.1111/bjh.12266
Interleukin-6 (IL6) plays a central role in multiple myeloma pathogenesis and confers resistance to corticosteroid-induced apoptosis. We therefore evaluated the efficacy and safety of siltuximab, an anti-IL6 monoclonal antibody, alone and in combinat