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Publikováno v:
British Journal of Clinical Pharmacology. 88:2484-2499
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease and is usually diagnosed in childhood, especially in the first decade of life. Paediatric FMF is characterized by a protean clinical expression and a variable th
Publikováno v:
British Journal of Clinical Pharmacology. 88:1885-1896
Aim: Metamizole (dipyrone) is a prodrug not detectable in serum or urine after oral ingestion. The primary metabolite is 4-methylaminoantipyrine (4-MAA), which can be N-demethylated to 4-aminoantipyrine (4-AA) or oxidized to 4-formylaminoantipyrine (
Autor:
Silvia Scabini, Antonio D'Avolio, Rosario Urbino, Jessica Cusato, Francesca Canta, Luca Brazzi, Simone Mornese Pinna, Giorgia Montrucchio, Chiara Bonetto, Silvia Corcione, Giovanni Di Perri, Valeria Avataneo, Amedeo De Nicolò, Francesco Giuseppe De Rosa
Publikováno v:
British Journal of Clinical Pharmacology
Remdesivir is one of the most encouraging treatments against SARS‐CoV‐2 infection. After intravenous infusion, RDV is rapidly metabolized (T1/2 1h) within the cells to its active adenosine triphosphate analogue form (GS‐443902) and, then, it ca
Publikováno v:
British Journal of Clinical Pharmacology. 88:166-177
Aims The aims of this work were to build a semi-mechanistic tumor growth inhibition (TGI) model for metastatic colorectal cancer (mCRC) patients receiving either cetuximab+chemotherapy or chemotherapy alone and to identify early predictors of overall
Autor:
Han Yan, Hoan Linh Banh, Huan-De Li, Ping Xu, Feng Wang, Yangang Zhou, Bikui Zhang, Wu Liang, Da-Xiong Xiang
Publikováno v:
British Journal of Clinical Pharmacology. 87:2838-2846
BACKGROUND Tigecycline has been widely used to treat hospital-acquired pneumonia (HAP) off-label since it is effective against a wide range of multidrug-resistant bacteria. However, no recommended dosage for this indication has been evaluated, result
Autor:
Klaus G. Parhofer, Anja Kerksiek, Bediha Bölükbasi, Ulrich Laufs, Dieter Lütjohann, Frans Stellaard
Publikováno v:
British Journal of Clinical Pharmacology. 87:4252-4261
AIMS The serum ratios of the brain-specific oxysterol 24S-hydroxycholesterol (24S-OHC) to cholesterol and to 27-OHC reflect brain cholesterol turnover. We studied the effect of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK
Autor:
Hu Lili, Jiaolin Ning, Jian Cao, Lu Sunshan, Xingtong Chen, Yan Chen, Qian Chen, Bin Yi, Zhen Cahilog, Jianteng Gu, Kaizhi Lu
Publikováno v:
British Journal of Clinical Pharmacology
AIMS This study aims to evaluate the effects of dexmedetomidine on organ function, inflammation response, and oxidative stress in elderly patients following iatrogenic lower limb ischaemia-reperfusion (IR) during unilateral total knee arthroplasty. M
Autor:
Oscar Della Pasqua, Matthias Oelke, Chandrashekhar Chavan, Martin C. Michel, Michael J. Manyak, Claus G. Roehrborn, Juan Manuel Palacios-Moreno, Salvatore D'Agate
Publikováno v:
British Journal of Clinical Pharmacology
Aims Combination therapy of 5α‐reductase inhibitor and α‐blocker is a guideline‐endorsed therapeutic approach for patients with moderate‐to‐severe lower urinary tract symptoms or benign prostatic hyperplasia (LUTS/BPH) who are at risk of
Publikováno v:
British Journal of Clinical Pharmacology. 87:306-316
Introduction The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Despite years of research, the optimal dosing regimen (weekly versus 3
Autor:
Henry Pertinez, Munir Pirmohamed, Anthony G Marson, B. Kevin Park, Xiaoli Meng, Daniel F. Carr, James L. Maggs, Vincent Yip
Publikováno v:
British Journal of Clinical Pharmacology
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Aims Carbamazepine can cause hypersensitivity reactions in ~10% of patients. An immunogenic effect can be produced by the electrophilic 10,11-epoxide metabolite but not by carbamazepine. Hypothetically, certain single nucleotide polymorphisms might i