Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Philippe A. Cassier"'
Autor:
Stephane Ferretti, Sébastien Jeay, Ensar Halilovic, Claire Fabre, Laurence Van Bree, Christophe Meille, Jens Wuerthner, Florence Hourcade-Potelleret, Sebastian Bauer, Reinhard Dummer, Philippe A. Cassier, Astrid Jullion, George D. Demetri, Nelson Guerreiro, Daniel Shao-Weng Tan
Publikováno v:
British Journal of Cancer
Background CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support clinical exploration while providing preliminary evidence for dosing regimens. This first-in-human phase I study aimed at as
Autor:
Christiane Jungels, Véronique Trochon-Joseph, Carlos Gomez-Roca, Jean-Pierre Delord, Anne Vincent-Salomon, Nuria Kotecki, Olga Adamiec, Wael Jdey, Philippe A. Cassier, Christophe Le Tourneau, Christelle Zandanel, Edith Borcoman, Hélène Toussaint, Audrey Mole, Lauriane Eberst, Vincent Cockenpot, Ségolène Hescot, Olivier de Beaumont, Françoise Bono
Publikováno v:
British Journal of Cancer
BackgroundAsiDNA, a first-in-class oligonucleotide-mimicking double-stranded DNA breaks, acts as a decoy agonist to DNA damage response in tumour cells. It also activates DNA-dependent protein kinase and poly (adenosine diphosphate [ADP]-ribose) poly
Publikováno v:
British Journal of Cancer
Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on t