Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Fink A"'
Autor:
Camilla Fowst, Urs Haller, Sergio Marchini, J Tursi, Cristina Geroni, André Fedier, Daniel Fink
Publikováno v:
British Journal of Cancer
Defects in DNA mismatch repair (MMR) are associated with a predisposition to tumorigenesis and with drug resistance owing to high mutation rates and failure to engage DNA-damage-induced apoptosis. DNA minor groove binders (MGBs) are a class of antica
Publikováno v:
British Journal of Cancer
A large fraction of human tumours carries mutations in the p53 gene. p53 plays a central role in controlling cell cycle checkpoint regulation, DNA repair, transcription, and apoptosis upon genotoxic stress. Lack of p53 function impairs these cellular
Autor:
Mathias K. Fehr, Urs Haller, Daniel Fink, R. Hornung, Heinrich Walt, Viola A. Schwarz, André Fedier
Publikováno v:
British Journal of Cancer
Loss of DNA mismatch repair is a common finding in hereditary nonpolyposis colon cancer as well as in many types of sporadic human tumours. DNA mismatch repair-deficient cells have been reported to be resistant to many chemotherapeutic agents and to
Autor:
J. Boehm, H. W. Praeuer, Jack A. Roth, Paul M. Schneider, O. Stoeltzing, Ralf Metzger, Arnulf H. Hoelscher, S. Wegerer, Ulrich Fink, John T. Manning
Publikováno v:
British Journal of Cancer
A prospective study was performed in patients with non-small cell lung cancer (NSCLC) to evaluate the prognostic importance of multiple molecular marker (p53, c-Ki-ras, c-erbB-2) testing. 103 patients with potentially curative resections (RO resectio
Publikováno v:
British Journal of Cancer
We prospectively investigated the prognostic significance of free peritoneal tumour cells (FPTC) in a series of 118 patients with completely resected gastric carcinoma. Immunocytochemistry with the monoclonal antibody Ber-Ep4 was performed on cytospi
Autor:
Stefan Aebi, Stephen B. Howell, Glenn J. Bubley, D Fink, Beverly A. Teicher, Bruno Cenni, R D Christen, H K Kim
Publikováno v:
British Journal of Cancer
In addition to recognizing and repairing mismatched bases in DNA, the mismatch repair (MMR) system also detects cisplatin DNA adducts and loss of MMR results in resistance to cisplatin. A comparison was made of the ability of MMR-proficient and -defi
Publikováno v:
British Journal of Cancer
Loss of DNA mismatch repair is a common finding in hereditary non-polyposis colon cancer as well as in many types of sporadic human tumours. We compared the effect of loss of DNA mismatch repair on drug sensitivity as measured by a clonogenic assay w
Publikováno v:
British Journal of Cancer
Medulloblastoma is the most frequent paediatric brain tumour. Because of the uniform histology, a common genetic mechanism has been postulated. Loss of heterozygosity (LOH) studies support evidence that a candidate gene, which functions as a tumour-s
Publikováno v:
British journal of cancer, vol 76, iss 7
British Journal of Cancer
British Journal of Cancer
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstr
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
The efficacy and safety of gemcitabine at a starting dose of 800 mg m2 administered once a week for 3 weeks with 1 week's rest was investigated in chemonaive patients with advanced and/or metastatic pancreatic cancer. Of 34 patients, 32 were evaluabl