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Autor:
Sarah Galbraith, Kate Walker, Angela Kuryba, Jan van der Meulen, Thomas E Cowling, Michael Braun, Alexis Bellot, Linda D. Sharples, Ajay Aggarwal, Jemma M. Boyle
Publikováno v:
British Journal of Cancer
Background The existing literature does not provide a prediction model for mortality of all colorectal cancer patients using contemporary national hospital data. We developed and validated such a model to predict colorectal cancer death within 90, 18
Autor:
Tadamichi Denda, Mitsugu Kochi, Masahiro Takeuchi, Takeshi Suto, Masashi Fujii, Takao Takahashi, Dai Manaka, Hiroaki Tanioka, Masahito Kotaka, Akinori Takagane, Tamotsu Sagawa, Akihito Tsuji, Wataru Ichikawa, Hiroki Hara, Hideto Fujita, Ken Shimada, Yuji Negoro, Yoshihiko Segawa, Toshiki Masuishi, Takanori Watanabe, Masato Nakamura
Publikováno v:
British Journal of Cancer
Background Regorafenib or trifluridine/tipiracil as third-line treatment have limited efficacy in metastatic colorectal cancer (mCRC). Methods This Phase 2 trial evaluated the efficacy and safety of irinotecan plus cetuximab rechallenge as third-line
Autor:
Michael J. Overman, Keith Fournier, Jennifer L. Guerra, Cathy Eng, Wai C. Foo, Alexandre A. Jácome, Melissa W. Taggart, Aurelio Matamoros, John Paul Shen, Kenna R. Shaw, Kanwal Pratap Singh Raghav, Christopher P. Scally
Publikováno v:
British Journal of Cancer
Background Appendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key molecular differences between AA and CRC is critical. Methods We performed retrospective a
Autor:
Evelien Bongers, Victorine H. Roos, Patrick M.M. Bossuyt, Frank G. J. Kallenberg, Evelien Dekker, Cora M. Aalfs, Manon van der Vlugt
Publikováno v:
British Journal of Cancer
British journal of cancer, 122(12), 1865-1871. Nature Publishing Group
British journal of cancer, 122(12), 1865-1871. Nature Publishing Group
Background Faecal immunochemical testing (FIT) is suboptimal in detecting advanced neoplasia (AN). To increase the sensitivity and yield of a FIT-based screening programme, FIT could be combined with risk factors for AN. We evaluated the incremental
Autor:
Hendrik Bläker, Esther Herpel, Elizabeth Alwers, Michael Hoffmeister, Jenny Chang-Claude, Prudence R. Carr, Hermann Brenner, Wilfried Roth, Lina Jansen, Matthias Kloor, Efrat L. Amitay
Publikováno v:
British Journal of Cancer
Background Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear. Methods This population-based case–control st
Autor:
Stefan Scherer, Judith Stift, Wu Zhang, Dongyun Yang, Shannon Graver, Peter B. Vermeulen, Stefan Stremitzer, Friedrich Wrba, Heinz-Josef Lenz, Luc Dirix, Mark M. Kockx, Thomas Gruenberger
Publikováno v:
British Journal of Cancer
Background Patients with desmoplastic (angiogenic) histopathological growth pattern (HGP) colorectal liver metastases (CLM) might derive more benefit from bevacizumab-based chemotherapy than those with replacement (non-angiogenic) HGP. This study inv
Autor:
Qi Wang, Xiaoliang Gao, Yuanyuan Lu, Danxiu Li, Jinchi Zhou, Minghui Ge, Mingfu Tong, Sijun Hu, Daiming Fan, Yongzhan Nie, Gaofei Shen, Ping Chen, Tianyu Cao, Junrong Liang, Hao Guo, Lina Sun, Hao Liu, Xiaodi Zhao, Xin Wang
Publikováno v:
British Journal of Cancer
Background The small GTPase Ran is upregulated in multiple cancers and fundamental for cancer cell survival and progression, but its significance and molecular mechanisms in colorectal cancer (CRC) remain elusive. Methods Ran expression was detected
Autor:
Iris E. Glykofridis, Rob M. F. Wolthuis, Irma van de Beek, Hans J. J. P. Gille, Arjan C. Houweling, R. Jeroen A. van Moorselaar, P.C. Johannesma, Hanne Meijers-Heijboer
Publikováno v:
van de Beek, I, Glykofridis, I E, Wolthuis, R M F, Gille, H J J P, Johannesma, P C, Meijers-Heijboer, H E J, van Moorselaar, J R A & Houweling, A C 2020, ' No evidence for increased prevalence of colorectal carcinoma in 399 Dutch patients with Birt-Hogg-Dubé syndrome ', British Journal of Cancer, vol. 122, no. 4, pp. 590-594 . https://doi.org/10.1038/s41416-019-0693-1
British Journal of Cancer, 122(4), 590-594. Nature Publishing Group
British journal of cancer, 122(4), 590-594. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 122(4), 590-594. Nature Publishing Group
British journal of cancer, 122(4), 590-594. Nature Publishing Group
British Journal of Cancer
Background Previously, it has been suggested that colorectal polyps and carcinomas might be associated with Birt-Hogg-Dubé syndrome. We aimed to compare the occurrence of colorectal neoplasms between Dutch patients with Birt-Hogg-Dubé syndrome and
Autor:
Jean-Marc Phelip, Valérie Boige, Karine Le Malicot, Julien Taieb, Jean-Marc Gornet, Jaafar Bennouna, Olivier Bouché, Eric Francois, for Prodige investigators, Veronique Guerin-Meyer, Oana Cojocarasu, Marie-Christine Kaminsky, Joëlle Egreteau, Laetitia Dahan, Jean-Baptiste Bachet, François Ghiringhelli, Roger Faroux, Mohamed Gasmi, Thomas Aparicio, Christian Borel, Côme Lepage
Publikováno v:
British Journal of Cancer
Background Identifying patients with metastatic colorectal cancer who will have an early disease progression during induction chemotherapy (IC) and identifying patients who may have a chemotherapy-free interval (CFI) after IC are two major challenges
Autor:
Xinwei Hua, Christophe Rosty, Daniel D. Buchanan, Wing Yan Li, Sheetal Hardikar, Mark Clendenning, John L. Hopper, Graham G. Giles, Finlay A. Macrae, Steven Gallinger, Polly A. Newcomb, Ingrid Winship, Jane C. Figueiredo, Mark A. Jenkins, S. Ghazaleh Dashti, Graham Casey, Robert W. Haile, Aung Ko Win, Loic Le Marchand, John D. Potter, Noralane M. Lindor, Stephen N. Thibodeau
Publikováno v:
British Journal of Cancer
Background Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repai