Zobrazeno 1 - 10
of 49
pro vyhledávání: ''
Autor:
Stephane Ferretti, Sébastien Jeay, Ensar Halilovic, Claire Fabre, Laurence Van Bree, Christophe Meille, Jens Wuerthner, Florence Hourcade-Potelleret, Sebastian Bauer, Reinhard Dummer, Philippe A. Cassier, Astrid Jullion, George D. Demetri, Nelson Guerreiro, Daniel Shao-Weng Tan
Publikováno v:
British Journal of Cancer
Background CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support clinical exploration while providing preliminary evidence for dosing regimens. This first-in-human phase I study aimed at as
Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells
Autor:
Yuru Shang, Christina S Mullins, Peng Gong, Brigitte Vollmar, Xianbin Zhang, Lili Lu, Dietmar Zechner, Ke Jiang, Mathias Krohn, Michael Linnebacher, Stephanie Matschos
Publikováno v:
British Journal of Cancer
Background Recent evidence proves that intravenous human immunoglobulin G (IgG) can impair cancer cell viability. However, no study evaluated whether IgG application benefits cancer patients receiving chemotherapeutics. Methods Influence of pharmaceu
Autor:
Rokaya El-Ansari, Syed Haider, Deborah C.I. Goberdhan, Alessandro Valli, Madeleine L. Craze, Emad A. Rakha, Matteo Morotti, Andrew R. Green, Adrian L. Harris, Christos E. Zois, Shih-Jung Fan
Publikováno v:
British Journal of Cancer
Background Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and prolifera
Autor:
Shuochen Wang, Hesham M. Amin, Song Bai Liu, Yao-Hua Song, Hui Ding, Xiaoxiao Wang, Chaofan Wu, Ting Xue, Yangxin Li, Jin Zhou, Jiqing Zheng
Publikováno v:
British Journal of Cancer
Background DAXX is a transcription repressor that has been implicated in several types of cancers, but its role in the development of gastric cancer remains unknown. Methods We analysed the expression of DAXX in 83 pairs of gastric cancer samples, in
Autor:
Lutfi Alfarsi, Ian O. Ellis, Maryam Althobiti, Emad A. Rakha, Andrew R. Green, Rokaya El Ansari, Madeleine L. Craze
Publikováno v:
British Journal of Cancer
Background Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study aimed to find whether enhanced glutamine uptake in breast cancer (BC) can derive the existence
Autor:
Xiaowen Wang, Qingzong Zhu, Jiangjun Cao, Fei Chen, Wen Peng, Xiaosong Hu, Hongjuan Cui, Gang Fu, Guanghui Zhang, Jianbing Hou
Publikováno v:
British Journal of Cancer
Background Thyroid hormone receptor interactor 13 (TRIP13) is an AAA + ATPase that plays an important role in the mitotic checkpoint. TRIP13 is highly expressed in various human tumours and promotes tumorigenesis. However, the biological effect of TR
Autor:
Ah Rong Nam, Kyung Hun Lee, Ju Hee Bang, Jin Won Kim, Do Youn Oh, Ji Won Kim, Koung Jin Suh, Yung-Jue Bang
Publikováno v:
British Journal of Cancer
Background A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. Methods Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalati
Publikováno v:
British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2019, 120 (8), pp.806-814. ⟨10.1038/s41416-019-0404-y⟩
British Journal of Cancer, Cancer Research UK, 2019, 120 (8), pp.806-814. ⟨10.1038/s41416-019-0404-y⟩
Background Prognostic markers for glioblastoma are lacking. Both intrinsic tumour characteristics and microenvironment could influence cancer prognostic. The aim of our study was to generate a pure glioblastoma cell lines and immune classification in
Autor:
Wayne D. Tilley, Kathryn Middleton, Cheng Liu, Chris Pyke, Catherine Shannon, Jane E. Armes, Madeline Gough, Natasha Woodward, Cameron Snell, Theresa E. Hickey
Publikováno v:
British Journal of Cancer
Background Recent pre-clinical studies indicate that activated progesterone receptor (PR) (particularly the PR-B isoform) binds to oestrogen receptor-α (ER) and reprogrammes transcription toward better breast cancer outcomes. We investigated whether
Autor:
Elisabet Aliagas, Alberto Villanueva, Alan G. Dawson, X. Sole, Maria Saigi, Jose Carlos Ruffinelli, M. Gausachs, Mar Varela, Dean A. Fennell, Montse Sanchez-Cespedes, Cristina Muñoz-Pinedo, Ignacio Escobar, Eduard Dorca, Susana Padrones, Ramon Palmero, Roger Llatjós, Sara Busacca, Miguel Hernández-Madrigal, Samantha Aso, Ernest Nadal, Ricard Ramos, Annabel J. Sharkley, María Martínez-Iniesta, August Vidal, Eva Pros, Ania Alay, David Cordero
Publikováno v:
British Journal of Cancer
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Br J Cancer
Dipòsit Digital de la UB
Universidad de Barcelona
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Br J Cancer
Dipòsit Digital de la UB
Universidad de Barcelona
Background:There is no effective therapy for patients with malignant pleural mesothelioma (MPM) who progressed to platinum-based chemotherapy and immunotherapy. Methods:We aimed to investigate the antitumor activity of CDK4/6 inhibitors using in vitr