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Autor:
Ana Carolina Pavanelli, Flavia Rotea Mangone, Piriya Yoganathan, Simone Aparecida Bessa, Suely Nonogaki, Cynthia A. B. de Toledo Osório, Victor Piana de Andrade, Iberê Cauduro Soares, Evandro Sobrosa de Mello, Lois M. Mulligan, Maria Aparecida Nagai
Publikováno v:
Breast Cancer Research and Treatment. 192:43-52
Breast cancer (BC) is considered a heterogeneous disease composed of distinct subtypes with diverse clinical outcomes. Luminal subtype tumors have the best prognosis, and patients benefit from endocrine therapy. However, resistance to endocrine thera
Publikováno v:
Breast Cancer Research and Treatment. 191:319-326
CYP4Z1 is a human cytochrome P450 enzyme involved in breast cancer progression and prognosis, but its functional role in these processes is not understood. In order to gain more insight into CYP4Z1’s properties it was recombinantly expressed in a h
Autor:
Kee Wah Lee, Aye Aye Thike, Anton J. Lucanus, Puay Hoon Tan, Xing Fei Tan, George W. Yip, Shiyuan Guo, Von Bing Yap, Victoria P. C. King, Boon-Huat Bay
Publikováno v:
Breast Cancer Research and Treatment. 191:63-75
Invasion of carcinoma cells into surrounding tissue affects breast cancer staging, influences choice of treatment, and impacts on patient outcome. KIF21A is a member of the kinesin superfamily that has been well-studied in congenital extraocular musc
Autor:
Jun Guo, Noel Dybdal, Ben-Quan Shen, Daniela Bumbaca Yadav, Gail Lewis Phillips, William R Proctor, James R. Kiefer
Publikováno v:
Breast Cancer Research and Treatment
Purpose Assessment of non-clinical safety signals relies on understanding species selectivity of antibodies. This is particularly important with antibody–drug conjugates, where it is key to determine target-dependent versus target-independent toxic
Autor:
Emad A. Rakha, Michael S. Toss, Abdulbaqi AlKawaz, Reem Ali, Andrew R. Green, Srinivasan Madhusudan, Omar J. Mohammed, Islam M. Miligy
Publikováno v:
Breast Cancer Research and Treatment
Background The prediction of clinical behaviour of breast ductal carcinoma in situ (DCIS) and its progression to invasive disease remains a challenge. Alterations of DNA damage repair mechanisms are associated with invasive breast cancer (BC). This s
Autor:
Ishita Loriya, Amanjit Bal, Siddhant Khare, Ashim Das, Shalmoli Bhattacharya, Gurpreet Singh, Sandeep Kumar
Publikováno v:
Breast Cancer Research and Treatment. 187:625-633
The heterogeneity of triple-negative breast cancer (TNBC) confers variable response to chemotherapy that results in poor outcome and relapse. Due to lack of targeted therapy, there is a need to provide molecular classification of TNBC and identify pr
Autor:
Stephen F. Madden, Colm Power, Janice M. Walshe, Simon J Furney, John Crown, Alex J Eustace, Sinead Toomey, A Hill, William M. Gallagher, Katherine M. Sheehan, Ailis Fagan, Oscar S. Breathnach, Bryan T. Hennessy, Deirdre Duke, Liam Grogan, Bruce Moran, Patrick G. Morris, Norma O'Donovan, Ausra Teiserskiene, Joanna Fay, Elaine W. Kay, Denis M. Collins, K. Egan
Publikováno v:
Breast Cancer Research and Treatment
Background Pre-treatment tumour-associated lymphocytes (TILs) and stromal lymphocytes (SLs) are independent predictive markers of future pathological complete response (pCR) in HER2-positive breast cancer. Whilst studies have correlated baseline lymp
Autor:
Yasuaki Uemoto, Akiko Kato, Sayaka Nishikawa, Yu Dong, Naoto Kondo, Satoshi Osaga, Tomoka Hisada, Tatsuya Toyama, Hiroshi Sugiura, Yusuke Katagiri, Mitsuo Terada, Takashi Fujita, Hiroyuki Kato, Yumi Wanifuchi-Endo, Katsuhiro Okuda, Satoru Takahashi, Tomoko Asano, Tae-Sun Kim
Publikováno v:
Breast Cancer Research and Treatment. 187:81-93
Retinoic acid-induced 2 (RAI2) has been shown to be a putative suppressor of the early hematogenous dissemination of tumor cells to the bone marrow in breast cancer. Here, we investigated the associations of RAI2 mRNA and protein expression with clin
Autor:
Susanna N Thomas, Rosemary L. Balleine, Shaun Chou, Nirmala Pathmanathan, Hema Mahajan, Belinda E Butcher, Gelareh Farshid, Masrura Kabir
Publikováno v:
Breast Cancer Research and Treatment. 188:729-737
This study aimed to determine the interobserver concordance of two methods for proliferation assessment in breast cancer using Ki67 immunohistochemistry. Ki67 was independently assessed in randomly selected tumour samples from patients with lymph nod
Autor:
Lars A. Akslen, Carina Strell, Reidunn J Edelmann, Axel Stenmark Tullberg, Mårten Fernö, Arne Östman, Per-Uno Malmström, Per Karlsson, Erik Holmberg
Publikováno v:
Breast Cancer Research and Treatment
Purpose Predictive biomarkers are needed to aid the individualization of radiotherapy (RT) in breast cancer. Cancer-associated fibroblasts have been implicated in tumor radioresistance and can be identified by platelet-derived growth factor receptor-