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Autor:
Ye Huang, Indira Prabakaran, Zhengdong Wu, Paul J. Zhang, Daniel I. Hoffman, Marina A. Guvakova, Julia Tchou
Publikováno v:
Breast Cancer Research and Treatment. 183:333-346
This proof-of-concept study investigates gene expression in core needle biopsies (CNB) to predict whether individuals diagnosed with ductal carcinoma in situ (DCIS) on CNB were affected by invasion at the time of diagnosis. Using a QuantiGene Plex 2.
Autor:
Asumi Sakaguchi, Ritsuko Sasaki, Mitsue Saito, Noriko Sasahara, Atsushi Arakawa, Harumi Saeki, Takanori Himuro, May Thinzar Hlaing, Yoshiya Horimoto
Publikováno v:
Breast Cancer Research and Treatment. 183:41-48
Multi-gene expression assays have been developed with the aim of predicting late recurrence in patients with estrogen receptor (ER)-positive breast cancer. However, establishment of alternative markers based on immunohistochemistry is also important
Publikováno v:
Breast Cancer Research and Treatment. 181:561-570
In this study we investigate the prediction and prognostic value of CXCL8–CXCR1/2 axis for Triple-negative breast cancer (TNBC) patients underwent neoadjuvant chemotherapy (NAC) following standard radical surgery. A total of 303 TNBC patients were
Autor:
Aidan C Li, Jing Zhao, Ramon Hartage, Yunxiang Zhang, Chao Zhao, Xiaoxian Li, Anil V. Parwani, Zhongliang Ma
Publikováno v:
Breast Cancer Res Treat
PURPOSE: Patients with HER2-positive breast cancer commonly receive anti-HER2 neoadjuvant chemotherapy and pathologic complete response (pCR) can be achieved in up to half of the patients. HER2 protein expression detected by immunohistochemistry (IHC
Autor:
Mazen Sudah, Amro Masarwah, Markku Tammi, Päivi Auvinen, Juho Ikonen, Anna Sutela, Satu Tiainen, Ritva Vanninen, Kirsi Rilla, Kirsi Hämäläinen, Sanna Oikari, Raija Tammi
Publikováno v:
Breast Cancer Research and Treatment
Purpose Tumor microenvironment, including inflammatory cells, adipocytes and extracellular matrix constituents such as hyaluronan (HA), impacts on cancer progression. Systemic metabolism also influences tumor growth e.g. obesity and type 2 diabetes (
Publikováno v:
Breast Cancer Research and Treatment. 179:511-517
The malignant upgrade rate of flat epithelial atypia (FEA) diagnosed on core needle biopsy varies between 0 and 30%. Excision versus observation with radiological follow-up for these lesions remains controversial. We hypothesize that the local rate o
Autor:
Shivani Vignesh, Nabendu Murmu, Debarpan Mitra, Sayantan Bhattacharyya, Neyaz Alam, Biswanath Majumder, Sagar Sen, Saunak Mitra, Syamsundar Mandal
Publikováno v:
Breast Cancer Research and Treatment. 179:359-370
The occurrence of vasculogenic mimicry (VM) and EphA2-mediated tumour progression are associated with poor prognosis in various solid tumours. Here, we aimed to investigate the prognostic implications of VM and its association with phosphorylated Eph
Autor:
Allott, Emma, Shan, Yue, Chen, Mengjie, Sun, Xuezheng, Garcia-Recio, Susana, Kirk, Erin L, Olshan, Andrew F, Geradts, Joseph, Earp, H Shelton, Carey, Lisa A, Perou, Charles M, Pfeiffer, Ruth M, Anderson, William F., Troester, Melissa A.
Publikováno v:
Breast Cancer Research and Treatment
Allott, E, Shan, Y, Chen, M, Sun, X, Garcia-Recio, S, Kirk, E L, Olshan, A F, Geradts, J, Earp, H S, Earp, H S, Carey, L A, Perou, C M, Pfeiffer, R M, . Anderson, W F & Troester, M A 2019, ' Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications ', Breast Cancer Research and Treatment . https://doi.org/10.1007/s10549-019-05442-2
Allott, E, Shan, Y, Chen, M, Sun, X, Garcia-Recio, S, Kirk, E L, Olshan, A F, Geradts, J, Earp, H S, Earp, H S, Carey, L A, Perou, C M, Pfeiffer, R M, . Anderson, W F & Troester, M A 2019, ' Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications ', Breast Cancer Research and Treatment . https://doi.org/10.1007/s10549-019-05442-2
Purpose Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or groupings of tumors with shared risk factors. While RNA-based methods including PAM50 have identified
Autor:
Masahiro Kashiwaba, Akihide Tanimoto, Yasuaki Sagara, Akira I. Hida, Kenjiro Aogi, Yasuyo Ohi, Yoshiaki Sagara, Takahiro Watanabe
Publikováno v:
Breast Cancer Research and Treatment. 178:283-294
High-density tumor-infiltrating lymphocytes (TILs) are a prognostic marker for triple-negative breast cancer (TNBC). However, lymphocytic infiltration is heterogeneous in its pattern. We aimed to explore the utility of TIL distribution patterns again
Autor:
Jasmin Zeindler, Simone Muenst, Walter P. Weber, Raoul A. Droeser, Salvatore Piscuoglio, Fiorenzo Valente Ernst Jakob Angehrn, Andrej Isaak, Samuel Meili, Robert Mechera, Silvio Däster, Charlotte K.Y. Ng, Ergin Kilic, Savas D. Soysal
Publikováno v:
Breast Cancer Research and Treatment. 177:581-589
Myeloperoxidase (MPO) is an enzyme secreted by neutrophil granulocytes as a result of phagocytosis during inflammation. In colorectal cancer, tumour infiltration by MPO expressing cells has been shown to be independently associated with a favourable