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Autor:
Asumi Sakaguchi, Ritsuko Sasaki, Mitsue Saito, Noriko Sasahara, Atsushi Arakawa, Harumi Saeki, Takanori Himuro, May Thinzar Hlaing, Yoshiya Horimoto
Publikováno v:
Breast Cancer Research and Treatment. 183:41-48
Multi-gene expression assays have been developed with the aim of predicting late recurrence in patients with estrogen receptor (ER)-positive breast cancer. However, establishment of alternative markers based on immunohistochemistry is also important
Autor:
Gerrit K. J. Hooijer, Hugo M. Horlings, Jan Koster, M.J. van de Vijver, Hans Halfwerk, Sybren L. Meijer, C. D. Savci-Heijink
Publikováno v:
Breast Cancer Research and Treatment
Breast cancer research and treatment, 174(3), 649-659. Springer New York
Breast cancer research and treatment, 174(3), 649-659. Springer New York
Background Epithelial-to-mesenchymal transition (EMT) has been implicated as an important step in the development of distant metastases. We therefore wished to study EMT status of primary breast carcinomas from patients who during follow-up developed
Autor:
Puay Hoon Tan, Valerie Cui Yun Koh, Wai Jin Tan, Jeffrey Chun Tatt Lim, Aye Aye Thike, Jane Sie Yong Tan
Publikováno v:
Breast Cancer Research and Treatment. 150:19-29
Epithelial–mesenchymal transition (EMT), an important process during embryonic development, is reportedly exploited during tumour progression. Deregulation of EMT-related molecules has been shown in many malignancies, including breast carcinoma. We
Autor:
Fanfan Meng, Gan Xie, Lanjing Zhang, Hongqin Jia, Bingbing Liu, Yi Ling Yang, Xia Zheng, Li Fu, Yawen Song, Xinmin Zhang, Shuai Li, Xiao-long Qian
Publikováno v:
Breast cancer research and treatment. 166(2)
Invasive micropapillary carcinoma (IMPC) of the breast has distinct histological features and molecular genetic profiles. Gains/amplifications of 8q24 are found associated with IMPC. Although the prostate stem cell antigen (PSCA) gene is located at c
Autor:
Emad A. Rakha, Maria Diez-Rodriguez, Mohammed A. Aleskandarany, Christopher C. Nolan, Ahmed Elmouna, Ibraheem Ashankyty, Ian O. Ellis, Andrew R. Green
Publikováno v:
Breast cancer research and treatment. 158(2)
In breast cancer (BC), the prognostic value of Ki67 expression is well-documented. Intratumoural heterogeneity (ITH) of Ki67 expression is amongst the several technical issues behind the lag of its inclusion into BC prognostic work-up. The immunohist
Autor:
Desmond G. Powe, E. Claire Paish, Emad A. Rakha, R. Douglas Macmillan, Ian O. Ellis, A O J Agboola, Andrew R. Green
Publikováno v:
Breast Cancer Research and Treatment. 133:575-582
Advances in the understanding of the molecular basis of breast cancer have necessitated a definition of more sensitive and specific indicators of prognosis that are central to the underlying cancer biology and that reflect the complicated and heterog
Autor:
Celina G. Kleer, Leslie M. Shaw, Jennifer L. Clark, Chung-Cheng Hsieh, Ashraf Khan, Karen Dresser, Michael S. Sabel
Publikováno v:
Breast Cancer Research and Treatment. 130:759-772
Recent studies have identified a role for insulin receptor substrate-2 (IRS-2) in promoting motility and metastasis in breast cancer. However, no published studies to date have examined IRS-2 expression in human breast tumors. We examined IRS-2 expre
Publikováno v:
Breast Cancer Research and Treatment. 123:701-708
EpCAM (CD326) has diverse roles in cell adhesion and proliferation and is known to be overexpressed in primary breast carcinomas. While clinical and preclinical data suggest a role for EpCAM in metastases, the only prior study of EpCAM expression in
Publikováno v:
Breast Cancer Research and Treatment. 123:125-128
It is not known whether the HER2 status of malignant CSF cells coincides with that of the original breast carcinoma cells. We investigated whether CSF cytology specimens were suitable to evaluate HER2 status by fluorescence in situ hybridization (FIS
Publikováno v:
Breast Cancer Research and Treatment. 115:423-428
Purpose The prognosis of women with triple-negative breast cancers (defined as cancers that are estrogen receptor-negative, progesterone receptor-negative and HER2/neu negative) is poor, compared to women with other subtypes of breast cancer. It is p