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Autor:
Andrew R. Green, Lutfi Alfarsi, Madeleine L. Craze, Brendah K. Masisi, Emad A. Rakha, Rokaya El Ansari, Ian O. Ellis
Publikováno v:
Breast Cancer Research and Treatment
Purpose Breast cancer (BC) is a heterogeneous disease consisting of various subtypes, with different prognostic and therapeutic outcomes. The amino acid transporter, SLC7A8, is overexpressed in oestrogen receptor-positive BC. However, the consequence
Autor:
Julia Y S Tsang, Sai-Yin Cheung, Siu-Ki Chan, Joanna Tong, Yun-Bi Ni, Mu-Min Shao, Ka Fai To, Gary Tse
Publikováno v:
Breast cancer research and treatment. 169(1)
Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers from sites with frequent breast metastase
Autor:
Jeremy Thomas, J.M. Dixon, J. Keys, Laura M. Arthur, Andrew H. Sims, Lorna Renshaw, Arran K Turnbull, Mark R. Lackner, Timothy R. Wilson
Publikováno v:
Breast Cancer Research and Treatment. 147:211-219
The phosphatidylinositol-3-kinase pathway plays an important role in proliferation, migration and survival in breast cancer and may play a role in resistance to endocrine therapy. Pathway activation occurs as a result of mutations in PIK3CA or loss o
Autor:
Li Fu, Yaqing Li, Xiaojing Guo, Ronggang Lang, Xinmin Zhang, Meijing Ren, Feng Gu, Fangfang Liu
Publikováno v:
Breast Cancer Research and Treatment. 135:459-467
It has been reported that the prognostic significances of tumor-infiltrating FOXP3(+) regulatory T cells (Tregs) in breast carcinoma depend on their relative density and tissue locations. We here assessed the changes of Tregs before and after neoadju
Autor:
Lei Huo, Jun Xu, Xiaoyong Fu, Rachel Schiff, Roland L. Bassett, Chad J. Creighton, Ma Wan, Quanyuan He, Feng-Tao Shi, Albert C. Chen, Dan Liu
Publikováno v:
Breast Cancer Research and Treatment. 134:531-541
While breast cancer mortality rate has seen a steady decline in the last few decades, advances in better treatment and diagnostic tools remain important as we come into the age of personalized therapy. In this report, we describe our studies of SGK3'
Publikováno v:
Breast Cancer Research and Treatment. 133:179-188
Tumor hypoxia-inducible transcription factor (HIF) overexpression often associates with a poor prognosis. Stability of the HIF-α subunits is regulated by HIF prolyl 4-hydroxylases, PHD1-3. We assessed here immunohistochemical expression of PHD1-3 an
Autor:
Katharina Tiemann, G Hoffmann, Kurt Diebold, Carsten Denkert, S. Henschen, Frank Holms, Marianne Just, Michael R. Clemens, Klaus Dietrich, Jens Huober, Silvia Darb-Esfahani, Sibylle Loibl, Michael Untch, Christine Solbach, Holger Eidtmann, Gunter von Minckwitz, Iris Schrader, Claus Hanusch, Hans Tesch
Publikováno v:
Breast Cancer Research and Treatment. 132:863-870
Adjacent ductal carcinoma in situ (DCIS) is found in approximately 45% of invasive ductal carcinomas (IDC) of the breast. Pure DCIS overexpresses HER2 in approximately 45%. There is uncertainty whether adjacent DCIS impacts on the response to neoadju
Autor:
Celina G. Kleer, Leslie M. Shaw, Jennifer L. Clark, Chung-Cheng Hsieh, Ashraf Khan, Karen Dresser, Michael S. Sabel
Publikováno v:
Breast Cancer Research and Treatment. 130:759-772
Recent studies have identified a role for insulin receptor substrate-2 (IRS-2) in promoting motility and metastasis in breast cancer. However, no published studies to date have examined IRS-2 expression in human breast tumors. We examined IRS-2 expre
Autor:
Sylke Krenkel, Sibyll Hein, M. Ihnen, Sabine Riethdorf, Nadine Köhler, Michaela Schweizer, Klaus Pantel, Katrin Beck, Thomas Streichert, Fritz Jänicke, Rana Issa, Harriet Wikman, Volkmar Müller, Volker Assmann, Karin Milde-Langosch
Publikováno v:
Breast Cancer Research and Treatment. 129:347-360
The activated leukocyte cell adhesion molecule (ALCAM) is overexpressed in many mammary tumors, but controversial results about its role and prognostic impact in breast cancer have been reported. Therefore, we evaluated the biologic effects of ALCAM
Autor:
Rawiah Alisary, Andrew R. Green, Abeer M Shaaban, Julie Richardson, Mohamed Kamal, Clare Walker, Ian O. Ellis, Sandra M. Bell, Valerie Speirs
Publikováno v:
Breast Cancer Research and Treatment. 127:639-648
The authors have investigated the expression of the microcephalin (MCPH1) protein to evaluate its prognostic importance in breast cancer. Microcephalin is a damage response protein involved in the regulation of BRCA1 and BRCA2. BRCA1 mutations are of