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Publikováno v:
Breast Cancer Research
Introduction Mutations in BRCA1, BRCA2, ATM, TP53, CHK2 and PTEN account for many, but not all, multiple-case breast and ovarian cancer families. The histone acetyltransferase gene EP300 may function as a tumour suppressor gene because it is sometime
Publikováno v:
Breast Cancer Research : BCR
Introduction Diabetes during pregnancy is related to enhanced fetal growth, which has been associated with increased breast cancer risk. Whether daughters of mothers with a diagnosis of diabetes have an increased risk of breast cancer is not known. M
Autor:
Hanna Birke, Anthony Howell, Adam R. Brentnall, Stephen W. Duffy, Jennifer Stone, Ruth Warren, Jack Cuzick, Elizabeth Pinney, Jane Warwick
Publikováno v:
Breast Cancer Research : BCR
Introduction Mammographic density is well-established as a risk factor for breast cancer, however, adjustment for age and body mass index (BMI) is vital to its clinical interpretation when assessing individual risk. In this paper we develop a model t
Autor:
Timothy R. Rebbeck, Martin S. Tallman, Richard Aplenc, Robert Gray, Angela DeMichele, Phyllis A. Gimotty, Michelle Horn, Priya P Gor, William P. Vaughan, H. Irene Su
Publikováno v:
Gor, Priya P; Su, H Irene; Gray, Robert J; Gimotty, Phyllis A; Horn, Michelle; Aplenc, Richard; et al.(2010). Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study. Breast Cancer Research, 12(3), R26. doi: http://dx.doi.org/10.1186/bcr2570. Retrieved from: http://www.escholarship.org/uc/item/8j08f5kc
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Cyclophosphamide-based adjuvant chemotherapy is a mainstay of treatment for women with node-positive breast cancer, but is not universally effective in preventing recurrence. Pharmacogenetic variability in drug metabolism is one possible
Autor:
Melissa A. Crosby, Patricia A. Parker, Kalatu Davies, Robert J. Volk, Isabelle Bedrosian, Abenaa M. Brewster, Susan K. Peterson, Yu Shen, Scott B. Cantor
Publikováno v:
Breast Cancer Research : BCR
Background Family history of breast cancer is associated with an increased risk of contralateral breast cancer (CBC) even in the absence of mutations in the breast cancer susceptibility genes BRCA1/2. We compared quality-adjusted survival after contr
Autor:
Maria García-Aranda, Teresa Téllez, Maria Luisa Hortas, Alfonso Serrano, Maximino Redondo, Maria J. Roldan, Martin E. Gleave, Miguel Morell
Publikováno v:
Breast Cancer Research : BCR
Introduction Overexpression of the apoptosis-related protein clusterin is associated with breast cancer development and tumor progression. We describe the use of clusterin-specific antisense oligonucleotides and antibodies to sensitize breast carcino
Autor:
S Savaridas, Julie Cox
Publikováno v:
Breast Cancer Research : BCR
The importance of internal mammary nodes (IMNs) in the staging and treatment of breast cancer patients is controversial. Lymphoscintigraphic studies have demonstrated that a significant proportion of breast cancers have primary or partial IMN drainag
Autor:
Catherine Tomeo Ryan, A. Lindsay Frazier, Walter C. Willett, Helaine R.H. Rockett, Graham A. Colditz
Publikováno v:
Breast Cancer Research
Background Early life exposures, including diet, have been implicated in the etiology of breast cancer. Methods A nested case-control study was conducted among participants in the Nurses' Health Study who completed a 24-item questionnaire about diet
Autor:
Shashank Srivastava, Emad A. Rakha, Gayatri Sharma, Shakur Mohibi, Sameer Mirza, Nicolas I. Griffin, Mohammed A. Aleskandarany, Bhavana J. Dave, Vimla Band, Xiangshan Zhao, Hamid Band
Publikováno v:
Breast Cancer Research : BCR
Background We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cy
Autor:
Kosei Hirakawa, Naoki Aomatsu, Tsutomu Takashima, Katsumi Ikeda, Tetsuro Ishikawa, Masakazu Yashiro, Shinichiro Kashiwagi, Yoshinari Ogawa
Publikováno v:
Breast Cancer Research : BCR
Introduction Triple-negative breast cancer (TNBC), which is characterized by negativity for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2), is a high risk breast cancer that lacks specific targets for tre