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Publikováno v:
Breast Cancer Research
Introduction Inflammatory breast cancer is a special type of locally advanced mammary cancer that is associated with particularly aggressive behaviour and poor prognosis. The dog was considered the only natural model in which to study the disease bec
Autor:
Elaine F. Harkness, D. Gareth Evans, Paula Stavrinos, Jamie C. Sergeant, N Barr, Valerie Reece, Lynne Fox, Anil Jain, Michelle Harvie, Ursula Beetles, Yit Yoong Lim, Mary Wilson, Jack Cuzick, Susan M. Astley, Sara Bundred, Adam R. Brentnall, Louise S Donnelly, Sarah Sampson, Anthony Howell, Soujanya Gadde
Publikováno v:
Breast Cancer Research : BCR
Introduction The Predicting Risk of Cancer at Screening study in Manchester, UK, is a prospective study of breast cancer risk estimation. It was designed to assess whether mammographic density may help in refinement of breast cancer risk estimation u
Autor:
Alain Fourquet, Xavier Sastre-Garau, Jean-Yves Pierga, Dominique Stoppa-Lyonnet, Gaëlle Pierron, Isabelle de Mascarel, Alain Aurias, Michel Longy, Rémy Salmon, Anne Vincent-Salomon, Corinne Taris, Carlo Lucchesi, Patricia de Cremoux, Rémi Dendale, Brigitte Sigal-Zafrani, Virginie Raynal, Nadège Gruel, Olivier Delattre, Gaëtan MacGrogan
Publikováno v:
Breast Cancer Research
Introduction Typical medullary breast carcinoma (MBC) has recently been recognized to be part of the basal-like carcinoma spectrum, a feature in agreement with the high rate of TP53 mutations previously reported in MBCs. The present study was therefo
Autor:
Stephanie K. Guest, Sunil Pancholi, Zara Ghazoui, Allan Thornhill, Mitch Dowsett, Ricardo Ribas, Dean B. Evans, Marion T. Weigel, Heidi Lane, Ian Farmer, Stephen R. D. Johnston, Lesley-Ann Martin, Roger A'Hern
Publikováno v:
Breast Cancer Research : BCR
Introduction Strategies to improve the efficacy of endocrine agents in breast cancer (BC) therapy and to delay the onset of resistance include concomitant targeting of the estrogen receptor alpha (ER) and the mammalian target of rapamycin complex 1 (
Autor:
Alice L. Yu, Guo-Shiou Liao, Jung-Tung Hung, Ruey-Jen Lin, Chiun-Sheng Huang, John Yu, Kun-Tu Yeh, Fen-Pi Chou, Jin-Jin Lin, Huang-Chun Lien
Publikováno v:
Breast Cancer Research : BCR
Breast cancer research : BCR, vol 16, iss 2
Breast cancer research : BCR, vol 16, iss 2
Introduction Although breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little is known about their tumor biology. A malignant phyllodes tumor contains heterologous stromal elements, and can transform into rhabdomyos
Publikováno v:
Breast Cancer Research
Introduction Accumulating evidence suggests that fibroblasts play a pivotal role in promoting the growth of breast cancer cells. The objective of the present study was to characterize and validate an in vitro model of the interaction between small nu
Autor:
Frogne, Thomas, Laenkholm, Anne-Vibeke, Lyng, Maria Bibi, Henriksen, Katrine Lütken, Lykkesfeldt, Anne E
Publikováno v:
Frogne, T, Laenkholm, A-V, Lyng, M B, Henriksen, K L, Lykkesfeldt, A E & Lyng, M B 2009, ' Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors ', Breast Cancer Research (Online Edition), vol. 11, no. 1, pp. R11 . https://doi.org/10.1186/bcr2230
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction High expression of total HER2 protein confers poor prognosis for breast cancer patients. HER2 is a member of the HER family consisting of four receptors, HER1 to HER4. HER receptor activity is regulated by a variety of mechanisms, and ph
Publikováno v:
Breast Cancer Research : BCR
Background Black-white disparities in breast cancer incidence rates and birth outcomes raise concerns about potential disparities in the reproductive health of premenopausal breast cancer survivors. We examined the prevalence of preterm birth (PTB),
Autor:
Eran R. Andrechek, Daniel P. Hollern
Publikováno v:
Breast Cancer Research : BCR
Introduction Genomic variability limits the efficacy of breast cancer therapy. To simplify the study of the molecular complexity of breast cancer, researchers have used mouse mammary tumor models. However, the degree to which mouse models model human
Autor:
Alexander Dobrovic, Stephen B. Fox, Ewan K.A. Millar, Sandra A O'Toole, Andreas Möller, Mira C.P. Liu, Christina S.F. Wong, Robert L. Sutherland, Katie T. Huang, Peter Chan, Catriona M. McNeil, David D.L. Bowtell, Nic Waddell, Jaclyn Sceneay
Publikováno v:
Breast Cancer Research : BCR
Introduction: The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-a; however, its role in breast carcinoma is unclear. We investigated the frequency