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Autor:
Xiaolan Feng, Emeka K. Enwere, Patricia A. Tang, Anthony M. Magliocco, Holly E Wilson, Haocheng Li, Susan P. Lees-Miller, Alexander H.G. Paterson, Gwyn Bebb, Michelle Dean, Elizabeth N. Kornaga
Publikováno v:
Breast Cancer Research : BCR
Introduction The serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and BRCA1/2, thereby orchestrat
Publikováno v:
Breast Cancer Research : BCR
In 2008, allowing for an increase in the number of women treated with mastectomy and immediate reconstruction, the decision at our institution was made to carry out mammography of the native and the reconstructed breast at follow-up. A literature rev
Publikováno v:
Breast Cancer Research : BCR
The objectives were to compare radiologists' breast mammographic density readings with computed tomography (CT) subjective measures; and to correlate computer-derived measurement of CT density with subjective assessments.
Autor:
Christina A. Clarke, Theresa H.M. Keegan, Mindy C. DeRouen, Allison W. Kurian, David J. Press
Publikováno v:
Breast Cancer Research : BCR
Introduction Breast cancers are increasingly recognized as heterogeneous based on expression of receptors for estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2). Triple-negative tumors (ER-/PR-/HER2-) have been repo
Autor:
Hans-Olov Adami, Rulla M. Tamimi, Xiaomei Liao, Megan S. Rice, Kimberly A. Bertrand, Bernard Rosner, Tyler J. VanderWeele
Publikováno v:
Breast Cancer Research : BCR
Background High mammographic density (MD) is a strong risk factor for breast cancer. However, it is unclear whether high MD is an intermediate phenotype or whether breast cancer risk factors influence breast cancer risk and MD independently. Methods
Autor:
Letitia D. Smith, Irene L. Andrulis, Ee Ming Wong, Andrew K. Godwin, Andrea Tesoriero, Esther M. John, Mary B. Daly, Mary Beth Terry, Ruby T. Senie, Stephen B. Fox, Melissa C. Southey, David E. Goldgar, Frances P. O'Malley, Graham G. Giles, Saundra S. Buys, Regina M. Santella, Hilmi Ozcelik, John L. Hopper, Anna Marie Mulligan, Susan J. Ramus
Publikováno v:
Breast Cancer Research : BCR
Introduction: Selecting women affected with breast cancer who are most likely to carry a germline mutation in BRCA1 and applying the most appropriate test methodology remains challenging for cancer genetics services. We sought to test the value of se
Autor:
Shanu Modi, Betsy Althaus, Anthony D. Elias, Ellie Guardino, Alexander Strasak, Dan Lu, Ian E. Krop, Mark D. Pegram, Patricia LoRusso
Publikováno v:
Breast Cancer Research : BCR
Background In pre-clinical studies, the anti-tumor activity of T-DM1 was enhanced when combined with taxanes or pertuzumab. This phase 1b/2a study evaluated the safety/tolerability of T-DM1 + paclitaxel ± pertuzumab in HER2-positive advanced breast
Publikováno v:
Breast Cancer Research : BCR
Introduction Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathological associations of the PIK3CA/mammalian targe
Publikováno v:
Largent, JA; Ziogas, A; & Anton-Culver, H. (2005). Effect of reproductive factors on stage, grade and hormone receptor status in early-onset breast cancer.. Breast cancer research : BCR, 7(4). doi: 10.1186/bcr1198. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1hh414hb
Breast Cancer Research
Breast Cancer Research
INTRODUCTION: Women younger than 35 years who are diagnosed with breast cancer tend to have more advanced stage tumors and poorer prognoses than do older women. Pregnancy is associated with elevated exposure to estrogen, which may influence the progr
Autor:
A. Rocca, Elisabetta Munzone, Giuseppe Renne, Aron Goldhirsch, Giuseppe Curigliano, Giuseppina Bonizzi, Franco Nolè
Publikováno v:
Breast Cancer Research
Introduction The amounts of estrogen receptor (ER) and progesterone receptor (PgR) in a primary tumor are predictive of the response to endocrine therapies of breast cancer. Several patients with ER-positive primary tumors relapse after adjuvant endo