Zobrazeno 1 - 10
of 46
pro vyhledávání: ''
Autor:
Helena Hwang, Brian Z. Ring, Marshall T Schreeder, Nancy Watroba, Robert S. Seitz, Christine Murekeyisoni, Swati Kulkarni, Noel C Estopinal, Douglas T. Ross, David G. Hicks, Thaer Khoury, Rodney A. Beck
Publikováno v:
Breast Cancer Research : BCR
Introduction The addition of taxanes (Ts) to chemotherapeutic regimens has not demonstrated a consistent benefit in early-stage breast cancer. To date, no clinically relevant biomarkers that predict T response have been identified. Methods A dataset
Publikováno v:
Breast Cancer Research : BCR
Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique. Resul
Autor:
Laura J. Esserman, John J. Sninsky, Christina Yau, Dan H. Moore, Christopher C. Benz, Fred Waldman
Publikováno v:
Yau, Christina; Esserman, Laura; Moore, Dan H; Waldman, Fred; Sninsky, John; & Benz, Christopher C. (2010). A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. Breast Cancer Research, 12(5), R85. doi: http://dx.doi.org/10.1186/bcr2753. Retrieved from: http://www.escholarship.org/uc/item/5383w1mx
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Various multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets overexpressing estrogen or progesterone receptors. Hormone receptor negative (HRn
Autor:
Douglas F. Lake, I. Tolgay Ocal, Heather E. Cunliffe, Benjamin A. Katchman, Yu Hui H. Chang, Janine LoBello, Galen Hostetter, Aprill Watanabe
Publikováno v:
Breast Cancer Research : BCR
Introduction Quiescin sulfhydryl oxidase 1 (QSOX1) oxidizes sulfhydryl groups to form disulfide bonds in proteins. Tumor specific expression of QSOX1 has been reported for numerous tumor types. In this study, we investigate QSOX1 as a marker of breas
Publikováno v:
Breast Cancer Research : BCR
Introduction Breast cancer comprises clinically distinct subtypes, but most risk statistics consider breast cancer only as a single entity. To estimate subtype-specific lifetime breast cancer risks, we took advantage of population-based data for whic
Autor:
Emad A. Rakha, Keith R. Neal, Mohammed A. Aleskandarany, Fabrício F. T. Barros, Ian O. Ellis, Jorge S. Reis-Filho, Ahmed Benhasouna, Andrew R. Green
Publikováno v:
Breast Cancer Research : BCR
Introduction Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic value and the potential app
Autor:
Kosei Hirakawa, Naoki Aomatsu, Tsutomu Takashima, Katsumi Ikeda, Tetsuro Ishikawa, Masakazu Yashiro, Shinichiro Kashiwagi, Yoshinari Ogawa
Publikováno v:
Breast Cancer Research : BCR
Introduction Triple-negative breast cancer (TNBC), which is characterized by negativity for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2), is a high risk breast cancer that lacks specific targets for tre
Autor:
Xiaolan Feng, Emeka K. Enwere, Patricia A. Tang, Anthony M. Magliocco, Holly E Wilson, Haocheng Li, Susan P. Lees-Miller, Alexander H.G. Paterson, Gwyn Bebb, Michelle Dean, Elizabeth N. Kornaga
Publikováno v:
Breast Cancer Research : BCR
Introduction The serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and BRCA1/2, thereby orchestrat
Autor:
A. Rocca, Elisabetta Munzone, Giuseppe Renne, Aron Goldhirsch, Giuseppe Curigliano, Giuseppina Bonizzi, Franco Nolè
Publikováno v:
Breast Cancer Research
Introduction The amounts of estrogen receptor (ER) and progesterone receptor (PgR) in a primary tumor are predictive of the response to endocrine therapies of breast cancer. Several patients with ER-positive primary tumors relapse after adjuvant endo
Autor:
Fredrik Granath, Andor Pivarcsi, Clara Ibel Chamorro, Annelie Liljegren, Günther Weber, Romuald Mentaverri, Samuel Rotstein, Bengt Sandstedt, Zuzana Saidak, Fabio Sánchez, Mona Ståhle, Sami Zreika
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research
Breast Cancer Research, BioMed Central, 2009, pp.R6
Breast Cancer Research
Breast Cancer Research, BioMed Central, 2009, pp.R6
Introduction Human cathelicidin antimicrobial protein, hCAP18, and its C-terminal peptide LL-37 is a multifunctional protein. In addition to being important in antimicrobial defense, it induces chemotaxis, stimulates angiogenesis and promotes tissue