Zobrazeno 1 - 10
of 55
pro vyhledávání: ''
Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Autor:
Laurence N. Kolonel, Song-Yi Park, Melissa A. Little, Shannon M. Conroy, Gertraud Maskarinec, Ian Pagano
Publikováno v:
Breast Cancer Research : BCR
Introduction Mammographic density, a strong predictor for breast cancer incidence, may also worsen prognosis in women with breast cancer. This prospective analysis explored the effect of prediagnostic mammographic density among 607 breast cancer case
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research; 17(1), no 23 (2015)
Breast Cancer Research; 17(1), no 23 (2015)
Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several diffe
Autor:
Sophia Agelaki, Antonia Kalykaki, A. Xyrafas, Emmanouil Saloustros, Kostas Kalbakis, Galatea Kallergi, Dimitris Mavroudis, Stella Apostolaki, M. Perraki, Vassilis Georgoulias
Publikováno v:
Breast Cancer Research : BCR
Background The detection of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTC) before and/or after adjuvant chemotherapy in patients with operable breast cancer is associated with poor clinical outcome. Reliable prognostic markers for
Autor:
Helena Hwang, Brian Z. Ring, Marshall T Schreeder, Nancy Watroba, Robert S. Seitz, Christine Murekeyisoni, Swati Kulkarni, Noel C Estopinal, Douglas T. Ross, David G. Hicks, Thaer Khoury, Rodney A. Beck
Publikováno v:
Breast Cancer Research : BCR
Introduction The addition of taxanes (Ts) to chemotherapeutic regimens has not demonstrated a consistent benefit in early-stage breast cancer. To date, no clinically relevant biomarkers that predict T response have been identified. Methods A dataset
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Yeun-Chung Chang, Chiun-Sheng Huang, Yu-Sen Huang, Wei-Chun Ko, Yao-Hui Tseng, Jenny Ling-Yu Chen, Sung-Hsin Kuo, Fu-Shan Jaw
Publikováno v:
Breast Cancer Research : BCR
We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy. This case-control study included 121 case
Autor:
Susan L. Teitelbaum, Alfred I. Neugut, Lauren E. McCullough, Patrick T. Bradshaw, Mary Beth Terry, Jia Chen, Marilie D. Gammon, Yoon Hee Cho, Alexandra J. White, Hanina Hibshoosh, Nikhil K. Khankari, Regina M. Santella
Publikováno v:
Breast Cancer Research : BCR
Background Mechanisms underlying the inverse association between physical activity and survival after breast cancer are unresolved, but DNA methylation may play a role. We hypothesized that promoter methylation of breast cancer-related genes, as well
Autor:
Joseph Geradts, Leonard M. Neckers, Neil L. Spector, Timothy A.J. Haystead, Qing Cheng, H. Kim Lyerly, Jeffrey T. Chang
Publikováno v:
Breast Cancer Research : BCR
Introduction Although human epidermal growth factor receptor 2 (HER2) positive or estrogen receptor (ER) positive breast cancers are treated with clinically validated anti-HER2 or anti-estrogen therapies, intrinsic and acquired resistance to these th
Autor:
Hoda Anton-Culver, James Hess, David Peel, Nigel P.S. Crawford, Argyrios Ziogas, Kent W. Hunter
Publikováno v:
Crawford, NPS; Ziogas, A; Peel, DJ; Hess, J; Anton-Culver, H; & Hunter, KW. (2006). Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Research, 8(2). doi: 10.1186/bcr1389. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1pc1d626
Breast Cancer Research
Breast Cancer Research
Introduction: There is growing evidence that heritable genetic variation modulates metastatic efficiency. Our previous work using a mouse mammary tumor model has shown that metastatic efficiency is modulated by the GTPase-activating protein encoded b