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Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Autor:
Reik Löser, Larissa J. Vos, Sai Kiran Sharma, John R. Mackey, Monica Wang, Ingrit Hamann, Frank Wuest, Manuela Kuchar, Melinda Wuest, Susan Richter
Publikováno v:
Breast Cancer Research 17(2015), 107
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1–LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human canc
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Autor:
Thomas Kieber-Emmons, Ann Marie Kieber-Emmons, Eric R. Siegel, Bounleut Phanavanh, Soldano Ferrone, Fariba Jousheghany, Tina Gomes, Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Larry J. Suva, Craig A. Cooney
Publikováno v:
Breast Cancer Research : BCR
Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene
Autor:
Jean-Simon Diallo, Dominic G. Roy, John C. Bell, Lauren Elizabeth St-Germain, Amelia Sadie Aitken, Theresa Falls, Vanessa Garcia, Rozanne Arulanandam, Marie-Claude Bourgeois-Daigneault, Adrian Pelin
Publikováno v:
Breast Cancer Research : BCR
Background Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The
Autor:
Alejandro Contreras, Lacey E. Dobrolecki, Susan G. Hilsenbeck, Meghana V. Trivedi, Ahmed Al-rawi, Sabrina Herrera, C. Kent Osborne, Chad J. Creighton, Raksha Bhat, Carolina Gutierrez, Mario Giuliano, Xiang Zhang, Sufeng Mao, Rachel Schiff, Pavel Christiny, Bianca Maria Veneziani, Michael T. Lewis, Tamika Mitchell, Mothaffar F. Rimawi, Fengju Chen, Xiaomei Zhang, Chad A. Shaw, Rinath Jeselsohn
Publikováno v:
Breast Cancer Research : BCR
Introduction Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, the small numbers of CTCs a
Autor:
Jhih Rong Lin, Wen Zhang, Rubén Nogales-Cadenas, Zhengdong D. Zhang, Ying Cai, Cristina Montagna, Quanwei Zhang
Publikováno v:
Breast Cancer Research : BCR
Background MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular process
Autor:
Shashank Srivastava, Emad A. Rakha, Gayatri Sharma, Shakur Mohibi, Sameer Mirza, Nicolas I. Griffin, Mohammed A. Aleskandarany, Bhavana J. Dave, Vimla Band, Xiangshan Zhao, Hamid Band
Publikováno v:
Breast Cancer Research : BCR
Background We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cy
Autor:
Fredrik Granath, Andor Pivarcsi, Clara Ibel Chamorro, Annelie Liljegren, Günther Weber, Romuald Mentaverri, Samuel Rotstein, Bengt Sandstedt, Zuzana Saidak, Fabio Sánchez, Mona Ståhle, Sami Zreika
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research
Breast Cancer Research, BioMed Central, 2009, pp.R6
Breast Cancer Research
Breast Cancer Research, BioMed Central, 2009, pp.R6
Introduction Human cathelicidin antimicrobial protein, hCAP18, and its C-terminal peptide LL-37 is a multifunctional protein. In addition to being important in antimicrobial defense, it induces chemotaxis, stimulates angiogenesis and promotes tissue
Autor:
Tayebeh Pourmotabbed, Miranda A. Hallett, Tiffany N. Seagroves, Hisashi Hasegawa, Luciana P. Schwab, Bin Teng
Publikováno v:
Breast Cancer Research : BCR
Introduction Despite continued improvements in diagnosis, surgical techniques, and chemotherapy, breast cancer patients are still overcome by cancer metastasis. Tumor cell proliferation, invasion and metastasis are mediated, at least in part, through