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Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Hoda Anton-Culver, James Hess, David Peel, Nigel P.S. Crawford, Argyrios Ziogas, Kent W. Hunter
Publikováno v:
Crawford, NPS; Ziogas, A; Peel, DJ; Hess, J; Anton-Culver, H; & Hunter, KW. (2006). Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Research, 8(2). doi: 10.1186/bcr1389. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1pc1d626
Breast Cancer Research
Breast Cancer Research
Introduction: There is growing evidence that heritable genetic variation modulates metastatic efficiency. Our previous work using a mouse mammary tumor model has shown that metastatic efficiency is modulated by the GTPase-activating protein encoded b
Autor:
Alejandro Contreras, Lacey E. Dobrolecki, Susan G. Hilsenbeck, Meghana V. Trivedi, Ahmed Al-rawi, Sabrina Herrera, C. Kent Osborne, Chad J. Creighton, Raksha Bhat, Carolina Gutierrez, Mario Giuliano, Xiang Zhang, Sufeng Mao, Rachel Schiff, Pavel Christiny, Bianca Maria Veneziani, Michael T. Lewis, Tamika Mitchell, Mothaffar F. Rimawi, Fengju Chen, Xiaomei Zhang, Chad A. Shaw, Rinath Jeselsohn
Publikováno v:
Breast Cancer Research : BCR
Introduction Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, the small numbers of CTCs a
Autor:
Jhih Rong Lin, Wen Zhang, Rubén Nogales-Cadenas, Zhengdong D. Zhang, Ying Cai, Cristina Montagna, Quanwei Zhang
Publikováno v:
Breast Cancer Research : BCR
Background MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular process
Autor:
Tayebeh Pourmotabbed, Miranda A. Hallett, Tiffany N. Seagroves, Hisashi Hasegawa, Luciana P. Schwab, Bin Teng
Publikováno v:
Breast Cancer Research : BCR
Introduction Despite continued improvements in diagnosis, surgical techniques, and chemotherapy, breast cancer patients are still overcome by cancer metastasis. Tumor cell proliferation, invasion and metastasis are mediated, at least in part, through
Autor:
David I. Rodenhiser, Ann F. Chambers, Bekim Sadikovic, Ariel Mendlowitz, Wendy Kennette, Alan B. Tuck, Joseph Andrews
Publikováno v:
Biochemistry Publications
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Breast cancer metastasis is a complex, multi-step biological process. Genetic mutations along with epigenetic alterations in the form of DNA methylation patterns and histone modifications contribute to metastasis-related gene expression
Autor:
Konstantin Shilo, Dinesh K. Ahirwar, Mohd W. Nasser, Zhenhua Miao, Ramesh K. Ganju, Nissar Ahmad Wani, Helong Zhao
Publikováno v:
Breast Cancer Research : BCR
Introduction Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind to C-X-C chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. C
Autor:
Edith A. Perez, Panos Z. Anastasiadis, Sahra Borges, Peter Storz, Heike Döppler, Xochiquetzal J. Geiger, Cathy A. Andorfer, Zhifu Sun, EA Thompson
Publikováno v:
Breast Cancer Research : BCR
Introduction DNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene encodes protein kinase D1
Autor:
Kristjan Asgeirsson, John F.R. Robertson, Kwok L. Cheung, Claire Allen, Amit Agrawal, Ian O. Ellis, Anthony Hitch, Caroline J. Chapman
Publikováno v:
Breast Cancer Research : BCR
Background Breast tissue expression of the ERBB proto-oncogene family has been extensively studied. It was recently shown that expression of epidermal growth factor receptor (EGFR; c-erbB-1) and epidermal growth factor receptor (HER)2 (c-erbB-2) can