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Autor:
Mårten Fernö, Pär-Ola Bendahl, Åke Borg, Lao H. Saal, Cecilia Hegardt, Dorthe Grabau, Gabriella Honeth, Kristina Lövgren, Markus Ringnér, Sofia K. Gruvberger-Saal
Publikováno v:
Breast Cancer Research. 10(3)
Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44+/CD24- phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is uncl
Autor:
Sarah Kirk, Tania Szado, Lukas C. Amler, Young-Hyuck Im, Jennifer Eng-Wong, Giampaolo Bianchini, Pinuccia Valagussa, Tadeusz Pienkowski, Luca Gianni, Giulia Bianchi, Lila Zabaglo, Mitch Dowsett, Astrid Kiermaier, Mei Ching Liu, Ling Ming Tseng
Publikováno v:
Breast Cancer Research : BCR
Background NeoSphere showed significantly higher pathologic complete response (pCR) with neoadjuvant pertuzumab, trastuzumab, and docetaxel compared with trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel. We assess
Autor:
Annette M. Molinaro, Maria T Baquero, Karen Lostritto, David L. Rimm, Lyndsay Harris, Mark Gustavson, Franck Appia, Kimberly A Bassi, Robert L. Camp
Publikováno v:
Breast Cancer Research : BCR
Introduction Microtubule associated proteins (MAPs) endogenously regulate microtubule stabilization and have been reported as prognostic and predictive markers for taxane response. The microtubule stabilizer, MAP-tau, has shown conflicting results. W
Autor:
Emad A. Rakha, Keith R. Neal, Mohammed A. Aleskandarany, Fabrício F. T. Barros, Ian O. Ellis, Jorge S. Reis-Filho, Ahmed Benhasouna, Andrew R. Green
Publikováno v:
Breast Cancer Research : BCR
Introduction Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic value and the potential app
Autor:
Edgar Dahl, Amjad Naami, Matthias W. Beckmann, Erik Noetzel, Michael F. Press, Jürgen Veeck, Nuran Bektas, Arndt Hartmann, Ruth Knüchel, Glen Kristiansen, Arno Dimmler, Peter A. Fasching
Publikováno v:
Breast Cancer Research : BCR
Breast cancer research 10(4), R58-R58 (2008). doi:10.1186/bcr2117
Breast cancer research 10(4), R58-R58 (2008). doi:10.1186/bcr2117
Introduction ISG15 is an ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. However, alterations in the ISG15 signalling pathway have also been found in s
Publikováno v:
Breast Cancer Research : BCR
Introduction Classification of breast cancers according to the HER-2 oncogene status is of central importance in the selection of post-surgical therapies. A decrease in the proportion of HER-2-positive breast cancer has been suspected, but no data on
Autor:
James H Dozier, Sharon Lobert, Nancy Stubbs Thomas, Laree Hiser, Hamed Benghuzzi, Michelle Tucci, Anthony Frankfurter, Jennifer A Davis, John J. Correia
Publikováno v:
Breast Cancer Research : BCR
Background Antimitotic chemotherapeutic agents target tubulin, the major protein in mitotic spindles. Tubulin isotype composition is thought to be both diagnostic of tumor progression and a determinant of the cellular response to chemotherapy. This i
Autor:
Keun Yong Eom, So Yeon Park, Jae Sung Kim, Changhoon Song, In Ah Kim, Jee Hyun Kim, Sung Won Kim
Publikováno v:
Breast Cancer Research : BCR
Introduction Evaluating the expression of signaling molecule proteins from the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol-3-kinase (PI3K) pathway in invasive breast cancers may identify prognostic marker(s) associate
Autor:
Xiaolan Feng, Emeka K. Enwere, Patricia A. Tang, Anthony M. Magliocco, Holly E Wilson, Haocheng Li, Susan P. Lees-Miller, Alexander H.G. Paterson, Gwyn Bebb, Michelle Dean, Elizabeth N. Kornaga
Publikováno v:
Breast Cancer Research : BCR
Introduction The serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and BRCA1/2, thereby orchestrat
Autor:
A. Rocca, Elisabetta Munzone, Giuseppe Renne, Aron Goldhirsch, Giuseppe Curigliano, Giuseppina Bonizzi, Franco Nolè
Publikováno v:
Breast Cancer Research
Introduction The amounts of estrogen receptor (ER) and progesterone receptor (PgR) in a primary tumor are predictive of the response to endocrine therapies of breast cancer. Several patients with ER-positive primary tumors relapse after adjuvant endo