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Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Autor:
Li Fu, Zhengmao Zhu, Ang Luo, Jin-Tang Dong, Xiaoying Fu, Liya Fu, Xiaodong Sun, Xiao Wu, Zhiqian Zhang, Weidong Li, Dan Su
Publikováno v:
Breast Cancer Research : BCR
Introduction The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research; 17(1), no 23 (2015)
Breast Cancer Research; 17(1), no 23 (2015)
Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several diffe
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Thomas Kieber-Emmons, Ann Marie Kieber-Emmons, Eric R. Siegel, Bounleut Phanavanh, Soldano Ferrone, Fariba Jousheghany, Tina Gomes, Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Larry J. Suva, Craig A. Cooney
Publikováno v:
Breast Cancer Research : BCR
Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene
Autor:
Joseph Geradts, Leonard M. Neckers, Neil L. Spector, Timothy A.J. Haystead, Qing Cheng, H. Kim Lyerly, Jeffrey T. Chang
Publikováno v:
Breast Cancer Research : BCR
Introduction Although human epidermal growth factor receptor 2 (HER2) positive or estrogen receptor (ER) positive breast cancers are treated with clinically validated anti-HER2 or anti-estrogen therapies, intrinsic and acquired resistance to these th
Autor:
Douglas F. Lake, I. Tolgay Ocal, Heather E. Cunliffe, Benjamin A. Katchman, Yu Hui H. Chang, Janine LoBello, Galen Hostetter, Aprill Watanabe
Publikováno v:
Breast Cancer Research : BCR
Introduction Quiescin sulfhydryl oxidase 1 (QSOX1) oxidizes sulfhydryl groups to form disulfide bonds in proteins. Tumor specific expression of QSOX1 has been reported for numerous tumor types. In this study, we investigate QSOX1 as a marker of breas
Autor:
Carlos Caldas, Ana-Teresa Maia, Martin O'Reilly, Alvin J.X. Lee, Bruce A.J. Ponder, Inmaculada Spiteri, Linda Jones
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Normal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease. Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles. Differential al