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Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Autor:
Reik Löser, Larissa J. Vos, Sai Kiran Sharma, John R. Mackey, Monica Wang, Ingrit Hamann, Frank Wuest, Manuela Kuchar, Melinda Wuest, Susan Richter
Publikováno v:
Breast Cancer Research 17(2015), 107
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1–LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human canc
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research; 17(1), no 23 (2015)
Breast Cancer Research; 17(1), no 23 (2015)
Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several diffe
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Shashank Srivastava, Emad A. Rakha, Gayatri Sharma, Shakur Mohibi, Sameer Mirza, Nicolas I. Griffin, Mohammed A. Aleskandarany, Bhavana J. Dave, Vimla Band, Xiangshan Zhao, Hamid Band
Publikováno v:
Breast Cancer Research : BCR
Background We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cy
Autor:
Xiaolan Feng, Emeka K. Enwere, Patricia A. Tang, Anthony M. Magliocco, Holly E Wilson, Haocheng Li, Susan P. Lees-Miller, Alexander H.G. Paterson, Gwyn Bebb, Michelle Dean, Elizabeth N. Kornaga
Publikováno v:
Breast Cancer Research : BCR
Introduction The serine/threonine protein kinase ataxia telangiectasia mutated (ATM) is critical in maintaining genomic integrity. Upon DNA double-strand breaks, ATM phosphorylates key downstream proteins including p53 and BRCA1/2, thereby orchestrat
Publikováno v:
Breast Cancer Research : BCR
Introduction Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathological associations of the PIK3CA/mammalian targe
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
Autor:
Ronald A. Lubet, Sendurai A. Mani, Patricia Casbas-Hernandez, Keith D. Amos, Lisa A. Carey, Jason R. Pirone, Jessica Rein, Erick Roman-Perez, Melissa A. Troester
Publikováno v:
Breast Cancer Research : BCR
Introduction A gene expression signature indicative of activated wound responses is common to more than 90% of non-neoplastic tissues adjacent to breast cancer, but these tissues also exhibit substantial heterogeneity. We hypothesized that gene expre
Autor:
Kuen-Feng Chen, Jung Chen Su, Kung-Chi Chang, Chung Wai Shiau, Pei-Yi Chu, Chunyu Liu, Wei Tien Tai, Ling Ming Tseng
Publikováno v:
Breast Cancer Research : BCR
Signal transducers and activators of transcription 3 (STAT3) signaling is constitutively activated in various cancers including breast cancer and has emerged as a novel potential anti-cancer target. STAT3 has been demonstrated to be a target of soraf