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Autor:
Reik Löser, Larissa J. Vos, Sai Kiran Sharma, John R. Mackey, Monica Wang, Ingrit Hamann, Frank Wuest, Manuela Kuchar, Melinda Wuest, Susan Richter
Publikováno v:
Breast Cancer Research 17(2015), 107
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1–LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human canc
Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer
Autor:
Brian M Nolen, Jeffrey R Marks, Shlomo Ta'san, Alex Rand, The Minh Luong, Yun Wang, Kimberly Blackwell, Anna E Lokshin
Publikováno v:
Breast Cancer Research : BCR
Introduction Neoadjuvant chemotherapy has become the standard of care for the diverse population of women diagnosed with locally advanced breast cancer. Serum biomarker levels are increasingly being investigated for their ability to predict therapy r
Autor:
Thomas Kieber-Emmons, Ann Marie Kieber-Emmons, Eric R. Siegel, Bounleut Phanavanh, Soldano Ferrone, Fariba Jousheghany, Tina Gomes, Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Larry J. Suva, Craig A. Cooney
Publikováno v:
Breast Cancer Research : BCR
Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene
Autor:
Jean-Simon Diallo, Dominic G. Roy, John C. Bell, Lauren Elizabeth St-Germain, Amelia Sadie Aitken, Theresa Falls, Vanessa Garcia, Rozanne Arulanandam, Marie-Claude Bourgeois-Daigneault, Adrian Pelin
Publikováno v:
Breast Cancer Research : BCR
Background Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The
Publikováno v:
Breast Cancer Research. 14(1)
Honokiol, a small-molecule polyphenol isolated from magnolia species, is widely known for its therapeutic potential as an antiinflammatory, antithrombosis, and antioxidant agent, and more recently, for its protective function in the pathogenesis of c
Autor:
Keun Yong Eom, So Yeon Park, Jae Sung Kim, Changhoon Song, In Ah Kim, Jee Hyun Kim, Sung Won Kim
Publikováno v:
Breast Cancer Research : BCR
Introduction Evaluating the expression of signaling molecule proteins from the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol-3-kinase (PI3K) pathway in invasive breast cancers may identify prognostic marker(s) associate
Autor:
Shanu Modi, Betsy Althaus, Anthony D. Elias, Ellie Guardino, Alexander Strasak, Dan Lu, Ian E. Krop, Mark D. Pegram, Patricia LoRusso
Publikováno v:
Breast Cancer Research : BCR
Background In pre-clinical studies, the anti-tumor activity of T-DM1 was enhanced when combined with taxanes or pertuzumab. This phase 1b/2a study evaluated the safety/tolerability of T-DM1 + paclitaxel ± pertuzumab in HER2-positive advanced breast
Autor:
Naoyuki Danbara, Hideto Senzaki, Hideho Takada, Takashi Yuri, Norihisa Uehara, Miki Tsujita-Kyutoku, Teruo Miyazawa, Takahiko Hada, Yutaka Ogawa, Yasuhiko Kiyozuka, Airo Tsubura
Publikováno v:
Breast Cancer Research
Introduction The present study was conducted to examine the effect of conjugated docosahexaenoic acid (CDHA) on cell growth, cell cycle progression, mode of cell death, and expression of cell cycle regulatory and/or apoptosis-related proteins in KPL-
Autor:
Basileios Venizelos, V. Zobolas, J. Papadiamantis, Helen Gogas, Zoh Antonopoulou, Dimitrios Koukouras, Grigorios Xepapadakis, Urania Dafni, John Misitzis, Evagelos Tzoracoleftherakis, Christos Markopoulos
Publikováno v:
Breast Cancer Research : BCR
Introduction Extended adjuvant endocrine therapy for breast cancer with aromatase inhibitors may potentially alter the lipid profile of postmenopausal patients and thus increase the risk of developing cardiovascular disease. In this study, a subproto
Autor:
Carole Chaboteaux, Guy Laurent, Hugues Duvillier, Jean-Jacques Body, Fabrice Journe, Nicolas Magne
Publikováno v:
Breast cancer research, 8 (1
Breast Cancer Research
Breast Cancer Research
Bisphosphonates are inhibitors of osteoclast-mediated tumor-stimulated osteolysis, and they have become standard therapy for the management of bone metastases from breast cancer. These drugs can also directly induce growth inhibition and apoptosis of