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Autor:
Li Fu, Zhengmao Zhu, Ang Luo, Jin-Tang Dong, Xiaoying Fu, Liya Fu, Xiaodong Sun, Xiao Wu, Zhiqian Zhang, Weidong Li, Dan Su
Publikováno v:
Breast Cancer Research : BCR
Introduction The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Douglas F. Lake, I. Tolgay Ocal, Heather E. Cunliffe, Benjamin A. Katchman, Yu Hui H. Chang, Janine LoBello, Galen Hostetter, Aprill Watanabe
Publikováno v:
Breast Cancer Research : BCR
Introduction Quiescin sulfhydryl oxidase 1 (QSOX1) oxidizes sulfhydryl groups to form disulfide bonds in proteins. Tumor specific expression of QSOX1 has been reported for numerous tumor types. In this study, we investigate QSOX1 as a marker of breas
Autor:
Emad A. Rakha, Keith R. Neal, Mohammed A. Aleskandarany, Fabrício F. T. Barros, Ian O. Ellis, Jorge S. Reis-Filho, Ahmed Benhasouna, Andrew R. Green
Publikováno v:
Breast Cancer Research : BCR
Introduction Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic value and the potential app
Publikováno v:
Breast Cancer Research : BCR
Introduction Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2+ (Her2+) breast cancers. Overexpression of PTK6 enhances anchorage-independent survival, proliferation, and mi
Autor:
Shashank Srivastava, Emad A. Rakha, Gayatri Sharma, Shakur Mohibi, Sameer Mirza, Nicolas I. Griffin, Mohammed A. Aleskandarany, Bhavana J. Dave, Vimla Band, Xiangshan Zhao, Hamid Band
Publikováno v:
Breast Cancer Research : BCR
Background We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cy
Autor:
Tayebeh Pourmotabbed, Miranda A. Hallett, Tiffany N. Seagroves, Hisashi Hasegawa, Luciana P. Schwab, Bin Teng
Publikováno v:
Breast Cancer Research : BCR
Introduction Despite continued improvements in diagnosis, surgical techniques, and chemotherapy, breast cancer patients are still overcome by cancer metastasis. Tumor cell proliferation, invasion and metastasis are mediated, at least in part, through
Autor:
Konstantin Shilo, Dinesh K. Ahirwar, Mohd W. Nasser, Zhenhua Miao, Ramesh K. Ganju, Nissar Ahmad Wani, Helong Zhao
Publikováno v:
Breast Cancer Research : BCR
Introduction Although C-X-C motif chemokine 12 (CXCL12) has been shown to bind to C-X-C chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. C
Autor:
Manuel Hidalgo, Manuel Marcos, Maria Fernandez-Abad, Isabel Calvo, Elena Garcia, Fernando Lopez Rios, Cristina Marquez, Sofia Perea, Laura G. Estévez, C. Miró, Ana Suárez-Gauthier, M. Herrero
Publikováno v:
Breast Cancer Research : BCR
Introduction Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly differentiated tumors and adverse prognosis features. This study aimed to determine