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Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Autor:
Li Fu, Zhengmao Zhu, Ang Luo, Jin-Tang Dong, Xiaoying Fu, Liya Fu, Xiaodong Sun, Xiao Wu, Zhiqian Zhang, Weidong Li, Dan Su
Publikováno v:
Breast Cancer Research : BCR
Introduction The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated
Autor:
Reik Löser, Larissa J. Vos, Sai Kiran Sharma, John R. Mackey, Monica Wang, Ingrit Hamann, Frank Wuest, Manuela Kuchar, Melinda Wuest, Susan Richter
Publikováno v:
Breast Cancer Research 17(2015), 107
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1–LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human canc
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Delphine Loussouarn, Mario Campone, Philippe Juin, Céline Séveno, Sophie Barillé-Nion, Sophie Bréchet
Publikováno v:
Breast Cancer Research
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
International audience; ABSTRACT: INTRODUCTION: Inappropriate Notch signalling, downstream of -secretase activity, is understood to have tumor-promoting function and to be associated with poor outcome in cancer, of the breast in particular. The molec
Autor:
Thomas Kieber-Emmons, Ann Marie Kieber-Emmons, Eric R. Siegel, Bounleut Phanavanh, Soldano Ferrone, Fariba Jousheghany, Tina Gomes, Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Larry J. Suva, Craig A. Cooney
Publikováno v:
Breast Cancer Research : BCR
Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene
Autor:
Jean-Simon Diallo, Dominic G. Roy, John C. Bell, Lauren Elizabeth St-Germain, Amelia Sadie Aitken, Theresa Falls, Vanessa Garcia, Rozanne Arulanandam, Marie-Claude Bourgeois-Daigneault, Adrian Pelin
Publikováno v:
Breast Cancer Research : BCR
Background Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The
Autor:
Alejandro Contreras, Lacey E. Dobrolecki, Susan G. Hilsenbeck, Meghana V. Trivedi, Ahmed Al-rawi, Sabrina Herrera, C. Kent Osborne, Chad J. Creighton, Raksha Bhat, Carolina Gutierrez, Mario Giuliano, Xiang Zhang, Sufeng Mao, Rachel Schiff, Pavel Christiny, Bianca Maria Veneziani, Michael T. Lewis, Tamika Mitchell, Mothaffar F. Rimawi, Fengju Chen, Xiaomei Zhang, Chad A. Shaw, Rinath Jeselsohn
Publikováno v:
Breast Cancer Research : BCR
Introduction Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, the small numbers of CTCs a