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Autor:
Janet R. Daling, Danielle M. Friedrichsen, Elaine A. Ostrander, Kathleen E. Malone, David R. Doody
Publikováno v:
Breast Cancer Research
Introduction The cell-cycle checkpoint kinase (CHEK)2 protein truncating mutation 1100delC has been associated with increased risk for breast or prostate cancer. Multiple studies have found an elevated frequency of the 1100delC variant in specific st
Autor:
Laurence N. Kolonel, Song-Yi Park, Melissa A. Little, Shannon M. Conroy, Gertraud Maskarinec, Ian Pagano
Publikováno v:
Breast Cancer Research : BCR
Introduction Mammographic density, a strong predictor for breast cancer incidence, may also worsen prognosis in women with breast cancer. This prospective analysis explored the effect of prediagnostic mammographic density among 607 breast cancer case
Publikováno v:
Breast Cancer Research : BCR
Introduction Over the last decade several breast cancer risk alleles have been identified which has led to an increased interest in individualised risk prediction for clinical purposes. Methods We investigate the performance of an up-to-date 18 breas
Publikováno v:
Breast Cancer Research : BCR
Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique. Resul
Autor:
Deirdre Cronin-Fenton, Timothy L. Lash, Søren Friis, John A. Baron, Henrik Toft Sørensen, Lars Pedersen
Publikováno v:
Breast Cancer Research : BCR
Cronin-Fenton, D, Pedersen, L, Lash, T L, Friis, S, Baron, J A & Sørensen, H T 2010, ' Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study ', Breast Cancer Research (Online Edition), vol. 12, no. 2, pp. R15 . https://doi.org/10.1186/bcr2482
Cronin-Fenton, D, Pedersen, L, Lash, T L, Friis, S, Baron, J A & Sørensen, H T 2010, ' Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study ', Breast Cancer Research (Online Edition), vol. 12, no. 2, pp. R15 . https://doi.org/10.1186/bcr2482
Udgivelsesdato: 2010-Mar-1 ABSTRACT: INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) prevent the growth of mammary tumours in animal models. Two population-based case-control studies suggest a reduced risk of breast cancer associated wit
Autor:
Yeun-Chung Chang, Chiun-Sheng Huang, Yu-Sen Huang, Wei-Chun Ko, Yao-Hui Tseng, Jenny Ling-Yu Chen, Sung-Hsin Kuo, Fu-Shan Jaw
Publikováno v:
Breast Cancer Research : BCR
We aimed to evaluate the influence of mammographic breast density at diagnosis on the risk of cancer recurrence and survival outcomes in patients with invasive breast cancer after modified radical mastectomy. This case-control study included 121 case
Autor:
Gulietta M. Pupo, Paul K. Lovelock, Georgia Chenevix-Trench, Amanda B. Spurdle, Felicity Lose, Graham J. Mann
Publikováno v:
Breast Cancer Research
Introduction Human RAD51 is a homologue of the Escherichia coli RecA protein and is known to function in recombinational repair of double-stranded DNA breaks. Mutations in the lower eukaryotic homologues of RAD51 result in a deficiency in the repair
Autor:
Kathleen Conway, Douglas A. Bell, Yu Li, Chiu-Kit Tse, Beth Newman, Robert C. Millikan, Lisa Cui
Publikováno v:
Breast Cancer Research
Introduction Epidemiologic studies have not shown a strong relationship between blood levels of polychlorinated biphenyls (PCBs) and breast cancer risk. However, two recent studies showed a stronger association among postmenopausal white women with t
Autor:
L. M. Peelen, Wouter B. Veldhuis, Carla H. van Gils, Gerco Haars, Petra H.M. Peeters, Mariëtte Lokate
Publikováno v:
Breast Cancer Research : BCR
Introduction Both the percent of mammographic density and absolute dense (fibroglandular) area are strong breast cancer risk factors. The role of non-dense (fat) breast tissue is not often investigated, but we hypothesize that this also influences ri
Autor:
Carlos Caldas, Ana-Teresa Maia, Martin O'Reilly, Alvin J.X. Lee, Bruce A.J. Ponder, Inmaculada Spiteri, Linda Jones
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Normal gene expression variation is thought to play a central role in inter-individual variation and susceptibility to disease. Regulatory polymorphisms in cis-acting elements result in the unequal expression of alleles. Differential al