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Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Autor:
Janet R. Daling, Danielle M. Friedrichsen, Elaine A. Ostrander, Kathleen E. Malone, David R. Doody
Publikováno v:
Breast Cancer Research
Introduction The cell-cycle checkpoint kinase (CHEK)2 protein truncating mutation 1100delC has been associated with increased risk for breast or prostate cancer. Multiple studies have found an elevated frequency of the 1100delC variant in specific st
Autor:
Li Fu, Zhengmao Zhu, Ang Luo, Jin-Tang Dong, Xiaoying Fu, Liya Fu, Xiaodong Sun, Xiao Wu, Zhiqian Zhang, Weidong Li, Dan Su
Publikováno v:
Breast Cancer Research : BCR
Introduction The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research; 17(1), no 23 (2015)
Breast Cancer Research; 17(1), no 23 (2015)
Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several diffe
Autor:
Mårten Fernö, Pär-Ola Bendahl, Åke Borg, Lao H. Saal, Cecilia Hegardt, Dorthe Grabau, Gabriella Honeth, Kristina Lövgren, Markus Ringnér, Sofia K. Gruvberger-Saal
Publikováno v:
Breast Cancer Research. 10(3)
Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44+/CD24- phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is uncl
Publikováno v:
Breast cancer research : BCR
Background Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Gulietta M. Pupo, Paul K. Lovelock, Georgia Chenevix-Trench, Amanda B. Spurdle, Felicity Lose, Graham J. Mann
Publikováno v:
Breast Cancer Research
Introduction Human RAD51 is a homologue of the Escherichia coli RecA protein and is known to function in recombinational repair of double-stranded DNA breaks. Mutations in the lower eukaryotic homologues of RAD51 result in a deficiency in the repair
Autor:
Delphine Loussouarn, Mario Campone, Philippe Juin, Céline Séveno, Sophie Barillé-Nion, Sophie Bréchet
Publikováno v:
Breast Cancer Research
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
International audience; ABSTRACT: INTRODUCTION: Inappropriate Notch signalling, downstream of -secretase activity, is understood to have tumor-promoting function and to be associated with poor outcome in cancer, of the breast in particular. The molec