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Publikováno v:
Breast Cancer Research
Introduction Mammographic density is a strong, independent risk factor for breast cancer. A critical unanswered question is whether cancers tend to arise in mammographically dense tissue (i.e. are densities directly related to risk or are they simply
Autor:
Stephanie A. Kennedy, Jennifer Gallagher, Lee G. Wilke, Marlee K. Junker, Nimmi Ramanujam, Torre Michelle Bydlon, Joseph Geradts, J. Quincy Brown, William T. Barry
Publikováno v:
Breast Cancer Research : BCR
Introduction Residual cancer following breast conserving surgery increases the risk of local recurrence and mortality. Margin assessment presents an unmet clinical need. Breast tissue is markedly heterogeneous, which makes distinguishing small foci o
Autor:
Moustapha Kassem, Marie Christine Klitgaard, René Villadsen, Mikkel Morsing, Ole W. Petersen, Abbas Jafari, Lone Rønnov-Jessen
Publikováno v:
Morsing, M, Klitgaard, M C, Jafari Kermani, A, Villadsen, R, Kassem, M S E-D, Petersen, O W & Rønnov-Jessen, L 2016, ' Evidence of two distinct functionally specialized fibroblast lineages in breast stroma ', Breast Cancer Research (Online), vol. 18, 108 . https://doi.org/10.1186/s13058-016-0769-2
Breast Cancer Research : BCR
Morsing, M, Klitgaard, M C, Jafari, A, Villadsen, R, Kassem, M, Petersen, O W & Rønnov-Jessen, L 2016, ' Evidence of two distinct functionally specialized fibroblast lineages in breast stroma ', Breast Cancer Research (Online), vol. 18, 108 . https://doi.org/10.1186/s13058-016-0769-2
Breast Cancer Research : BCR
Morsing, M, Klitgaard, M C, Jafari, A, Villadsen, R, Kassem, M, Petersen, O W & Rønnov-Jessen, L 2016, ' Evidence of two distinct functionally specialized fibroblast lineages in breast stroma ', Breast Cancer Research (Online), vol. 18, 108 . https://doi.org/10.1186/s13058-016-0769-2
Background The terminal duct lobular unit (TDLU) is the most dynamic structure in the human breast and the putative site of origin of human breast cancer. Although stromal cells contribute to a specialized microenvironment in many organs, this compon
Publikováno v:
Breast Cancer Research : BCR
Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique. Resul
Autor:
Greg Finak, Sarkis Meterissian, Morag Park, Michael Hallett, Karim Khetani, Margarita Souleimanova, Svetlana Sadekova, Atilla Omeroglu, Francois Pepin, Brent P. Zabolotny, Fawaz Halwani
Publikováno v:
Breast Cancer Research
Introduction The role of the cellular microenvironment in breast tumorigenesis has become an important research area. However, little is known about gene expression in histologically normal tissue adjacent to breast tumor, if this is influenced by th
Autor:
James H Dozier, Sharon Lobert, Nancy Stubbs Thomas, Laree Hiser, Hamed Benghuzzi, Michelle Tucci, Anthony Frankfurter, Jennifer A Davis, John J. Correia
Publikováno v:
Breast Cancer Research : BCR
Background Antimitotic chemotherapeutic agents target tubulin, the major protein in mitotic spindles. Tubulin isotype composition is thought to be both diagnostic of tumor progression and a determinant of the cellular response to chemotherapy. This i
Autor:
Shashank Srivastava, Emad A. Rakha, Gayatri Sharma, Shakur Mohibi, Sameer Mirza, Nicolas I. Griffin, Mohammed A. Aleskandarany, Bhavana J. Dave, Vimla Band, Xiangshan Zhao, Hamid Band
Publikováno v:
Breast Cancer Research : BCR
Background We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cy
Autor:
Hans-Olov Adami, Rulla M. Tamimi, Xiaomei Liao, Megan S. Rice, Kimberly A. Bertrand, Bernard Rosner, Tyler J. VanderWeele
Publikováno v:
Breast Cancer Research : BCR
Background High mammographic density (MD) is a strong risk factor for breast cancer. However, it is unclear whether high MD is an intermediate phenotype or whether breast cancer risk factors influence breast cancer risk and MD independently. Methods
Autor:
Choi Yoon-Ho, Yun-Mi Song, Joohon Sung, Tuong L. Nguyen, Mark A. Jenkins, Ye Kyaw Aung, John L. Hopper, Christopher F. Evans
Publikováno v:
Breast Cancer Research : BCR
Introduction When measured using the computer-assisted method CUMULUS, mammographic density adjusted for age and body mass index predicts breast cancer risk. We asked if new mammographic density measures defined by higher brightness thresholds gave b
Autor:
Orsola Anna Colantuoni, Laura Ottini, Angelo Raffaele Bianco, Cristina D'Amico, A. Contegiacomo, Maurizio Lalle, Sandro Carlini, Cristiana Noviello, Renato Mariani-Costantini, Fiorella Guadagni, Salvatore Lauro, Enrico Cortesi, Claudia Pizzi, Giuseppe Fornarini, Luigi Frati
Publikováno v:
Breast Cancer Research : BCR
Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BRCA1 and BRCA2 equally contributed to s