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Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer
Autor:
Brian M Nolen, Jeffrey R Marks, Shlomo Ta'san, Alex Rand, The Minh Luong, Yun Wang, Kimberly Blackwell, Anna E Lokshin
Publikováno v:
Breast Cancer Research : BCR
Introduction Neoadjuvant chemotherapy has become the standard of care for the diverse population of women diagnosed with locally advanced breast cancer. Serum biomarker levels are increasingly being investigated for their ability to predict therapy r
Autor:
Delphine Loussouarn, Mario Campone, Philippe Juin, Céline Séveno, Sophie Barillé-Nion, Sophie Bréchet
Publikováno v:
Breast Cancer Research
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
Breast Cancer Research, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research, BioMed Central, 2012, 14 (3), pp.R96. ⟨10.1186/bcr3214⟩
Breast Cancer Research : BCR
International audience; ABSTRACT: INTRODUCTION: Inappropriate Notch signalling, downstream of -secretase activity, is understood to have tumor-promoting function and to be associated with poor outcome in cancer, of the breast in particular. The molec
Autor:
Douglas F. Lake, I. Tolgay Ocal, Heather E. Cunliffe, Benjamin A. Katchman, Yu Hui H. Chang, Janine LoBello, Galen Hostetter, Aprill Watanabe
Publikováno v:
Breast Cancer Research : BCR
Introduction Quiescin sulfhydryl oxidase 1 (QSOX1) oxidizes sulfhydryl groups to form disulfide bonds in proteins. Tumor specific expression of QSOX1 has been reported for numerous tumor types. In this study, we investigate QSOX1 as a marker of breas
Publikováno v:
Breast Cancer Research : BCR
Introduction Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase that is highly expressed in Human Epidermal Growth Factor 2+ (Her2+) breast cancers. Overexpression of PTK6 enhances anchorage-independent survival, proliferation, and mi
Autor:
Naoyuki Danbara, Hideto Senzaki, Hideho Takada, Takashi Yuri, Norihisa Uehara, Miki Tsujita-Kyutoku, Teruo Miyazawa, Takahiko Hada, Yutaka Ogawa, Yasuhiko Kiyozuka, Airo Tsubura
Publikováno v:
Breast Cancer Research
Introduction The present study was conducted to examine the effect of conjugated docosahexaenoic acid (CDHA) on cell growth, cell cycle progression, mode of cell death, and expression of cell cycle regulatory and/or apoptosis-related proteins in KPL-
Autor:
Manuel Hidalgo, Manuel Marcos, Maria Fernandez-Abad, Isabel Calvo, Elena Garcia, Fernando Lopez Rios, Cristina Marquez, Sofia Perea, Laura G. Estévez, C. Miró, Ana Suárez-Gauthier, M. Herrero
Publikováno v:
Breast Cancer Research : BCR
Introduction Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly differentiated tumors and adverse prognosis features. This study aimed to determine
Autor:
Edith A. Perez, Panos Z. Anastasiadis, Sahra Borges, Peter Storz, Heike Döppler, Xochiquetzal J. Geiger, Cathy A. Andorfer, Zhifu Sun, EA Thompson
Publikováno v:
Breast Cancer Research : BCR
Introduction DNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene encodes protein kinase D1